State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing, 100029, P. R. China.
Small. 2024 Jan;20(3):e2305539. doi: 10.1002/smll.202305539. Epub 2023 Sep 12.
Artificial enzymes, as alternatives to natural enzymes, have attracted enormous attention in the fields of catalysis, biosensing, diagnostics, and therapeutics because of their high stability and low cost. Polyoxometalates (POMs), a class of inorganic metal oxides, have recently shown great potential in mimicking enzyme activity due to their well-defined structure, tunable composition, high catalytic efficiency, and easy storage properties. This review focuses on the recent advances in POM-based artificial enzymes. Different types of POMs and their derivatives-based mimetic enzyme functions are covered, as well as the corresponding catalytic mechanisms (where available). An overview of the broad applications of representative POM-based artificial enzymes from biosensing to theragnostic is provided. Insight into the current challenges and the future directions for POMs-based artificial enzymes is discussed.
人工酶作为天然酶的替代品，由于其高稳定性和低成本，在催化、生物传感、诊断和治疗等领域引起了极大的关注。多金属氧酸盐（POMs）是一类无机金属氧化物，由于其结构明确、组成可调、催化效率高和易于储存等特点，最近在模拟酶活性方面显示出巨大的潜力。本综述重点介绍了基于 POM 的人工酶的最新进展。涵盖了不同类型的 POM 及其衍生物的模拟酶功能，以及相应的催化机制（如果有的话）。提供了代表性基于 POM 的人工酶从生物传感到治疗学的广泛应用概述。讨论了基于 POM 的人工酶当前面临的挑战和未来的发展方向。
