Henan Key Laboratory of Polyoxometalate Chemistry, College of Chemistry and Molecular Sciences, Henan University, Kaifeng, Henan 475004, China.
Henan Key Laboratory of Polyoxometalate Chemistry, College of Chemistry and Molecular Sciences, Henan University, Kaifeng, Henan 475004, China; International Joint Research Laboratory for Cell Medical Engineering of Henan, Kaifeng, Henan 475000, China.
J Inorg Biochem. 2025 Jan;262:112739. doi: 10.1016/j.jinorgbio.2024.112739. Epub 2024 Sep 13.
The overuse of antibiotics can lead to the development of antibiotic-resistant bacteria, which can be even more difficult to treat and pose an even greater threat to public health. In order to address the issue of antibiotic-resistant bacteria, researchers currently are exploring alternative methods of sterilization that are both effective and sustainable. Polyoxometalates (POMs), as emerging transition metal oxide compounds, exhibit significant potential in various applications due to their remarkable tunable physical and chemical performance, especially in antibacterial fields. They constitute a diverse family of inorganic clusters, characterized by a wide array of composition, structures and charges. Presently, several studies indicated that POM-based composites have garnered extensive attention in the realms of the antibacterial field and may become promising materials for future medical applications. Moreover, this review will focus on exploring the antibacterial properties and mechanisms of different kinds of organic-inorganic hybrid POMs, POM-based composites, films and hydrogels with substantial bioactivity, while POM-based composites have the dual advantages of POMs and other materials. Additionally, the potential antimicrobial mechanisms have also been discussed, mainly encompassing cell wall/membrane disruption, intracellular material leakage, heightened intracellular reactive oxygen species (ROS) levels, and depletion of glutathione (GSH). These findings open up exciting possibilities for POMs as exemplary materials in the antibacterial arena and expand their prospective applications.
抗生素的过度使用会导致抗生素耐药菌的产生，而这些耐药菌更难治疗，对公众健康构成更大的威胁。为了解决抗生素耐药菌的问题，研究人员目前正在探索既有效又可持续的替代灭菌方法。多金属氧酸盐（POMs）作为新兴的过渡金属氧化物化合物，由于其显著的可调物理和化学性能，尤其是在抗菌领域，具有很大的应用潜力。它们构成了一个多样化的无机簇家族，具有广泛的组成、结构和电荷。目前，有几项研究表明，基于 POM 的复合材料在抗菌领域引起了广泛关注，可能成为未来医学应用的有前途的材料。此外，本综述将重点探讨不同种类的有机-无机杂化 POMs、基于 POM 的复合材料、具有大量生物活性的薄膜和水凝胶的抗菌性能和机制，而基于 POM 的复合材料具有 POMs 和其他材料的双重优势。此外，还讨论了潜在的抗菌机制，主要包括细胞壁/膜的破坏、细胞内物质的泄漏、细胞内活性氧（ROS）水平的升高以及谷胱甘肽（GSH）的消耗。这些发现为 POMs 作为抗菌领域的典范材料开辟了令人兴奋的可能性，并扩展了它们的潜在应用。
