Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, Alabama, USA.
Vet Dermatol. 2024 Feb;35(1):62-70. doi: 10.1111/vde.13204. Epub 2023 Sep 12.
Drug interactions are significant considerations for intradermal testing (IDT). Trazodone (TRZ) is an anxiolytic and selective histaminergic (H ) antagonist with no interaction in human prick tests; however, interaction in canine IDT is unknown.
HYPOTHESIS/OBJECTIVES: Trazodone will not adversely affect intradermal histamine reactions in dogs.
Fourteen nonanxious, nonatopic, healthy client-owned dogs were enrolled in this randomised, blinded, cross-over study.
Dogs were randomised to receive low-dose TRZ (4 mg/kg) (Teva Pharmaceuticals), high-dose TRZ (8 mg/kg) or no TRZ per os two hours before intravenous sedation with dexmedetomidine (5 mcg/kg) (Dexdomitor; Zoetis). Intradermal testing was performed with five quadrupling dilutions of histamine (1:100,000 to 1:25,600,000 w/v; Greer) and 0.9% saline (Hospira), observing a minimum two weeks washout period between treatments. Two observers, who were blinded to treatment and the identity of the injections, evaluated each test using previously established subjective and objective methods.
The mean wheal diameter of histamine 1:1,600,000 w/v was significantly smaller with low-dose TRZ (4 mg/kg) compared to the control group (p = 0.048; repeated measures ANOVA with post hoc Tukey's test). For all other histamine dilutions and saline, mean wheal diameter was not significantly different among groups. There were no significant differences in the subjective scores of all histamine dilutions and saline (p > 0.05; Friedman test).
A single oral dose of TRZ does not adversely affect intradermal histamine reactions in dogs.
药物相互作用是皮内试验（IDT）的重要考虑因素。曲唑酮（TRZ）是一种抗焦虑药和选择性组胺能（H ）拮抗剂，在人体划痕试验中没有相互作用；然而，在犬 IDT 中的相互作用尚不清楚。
假设/目的：曲唑酮不会对犬的皮内组胺反应产生不利影响。
本随机、双盲、交叉研究纳入了 14 只非焦虑、非特应性、健康的客户拥有的狗。
狗被随机分为口服低剂量 TRZ（4mg/kg）（Teva 制药公司）、高剂量 TRZ（8mg/kg）或无 TRZ，两小时后静脉给予右美托咪定（5μg/kg）（Dexdomitor；Zoetis）镇静。用五种四倍稀释的组胺（1:100,000 至 1:25,600,000 w/v；Greer）和 0.9%生理盐水（Hospira）进行皮内试验，在治疗之间观察至少两周的洗脱期。两名观察者对每一项测试进行评估，他们对治疗和注射的身份均不知情，并使用先前建立的主观和客观方法进行评估。
与对照组相比，低剂量 TRZ（4mg/kg）的组胺 1:1,600,000 w/v 平均风团直径明显较小（p=0.048；重复测量方差分析，事后 Tukey 检验）。对于所有其他组胺稀释液和生理盐水，各组之间的平均风团直径没有显著差异。所有组胺稀释液和生理盐水的主观评分均无显著差异（p>0.05；Friedman 检验）。
单次口服 TRZ 剂量不会对犬的皮内组胺反应产生不利影响。
