Few Julius, Lee Michael, Semersky Alec, Mariscal Emily, Pryor Sydney, Talati Akshay
Aesthet Surg J Open Forum. 2023 Jun 22;5:ojad055. doi: 10.1093/asjof/ojad055. eCollection 2023.
Aging, influenced by intrinsic and extrinsic factors, leads to visible skin changes such as dryness, surface roughness, and loss of luminosity. Proper skin care can mitigate some of these effects, with topical combination products offering support through complementary mechanisms.
To test efficacy and safety of GSYBS-7 (Goop Beauty Youth-Boost Peptide Serum; Goop Inc., Santa Monica, CA), a topical postbiotic and botanical combination serum, used twice daily on facial skin for 6 weeks.
In this 19-patient pilot study, the primary efficacy measure was improvement on the Global Ranking Scale (GRS) at 42 days. A 12-point patient satisfaction survey and the serum's effect on healing after ablative laser treatment served as secondary and exploratory measures, respectively.
Statistically significant improvements in all GRS domains were observed as early as day 7 with ongoing improvement up to day 42. A >1-point improvement was observed for dehydration (1.8; 95% CI, 1.5-2.2), visible pores (1.6; 95% CI, 1.3-2.0), surface roughness (1.6; 95% CI, 1.3-1.9), imbalance (1.3; 95% CI, .9-1.7), static wrinkles (1.3; 95% CI, .9-1.6), pigmentation (1.3; 95% CI, 1.0-1.5), and vasculature (1.2; 95% CI, .8-1.5). Independent photographic review and patient satisfaction surveys corroborated these findings. At day 42, 94.4% of patients were very satisfied with the results, and 88.9% would recommend GSYBS-7 to family and friends. No adverse events were reported, and 100% of patients indicated that GSYBS-7 was gentle enough for everyday use.
GSYBS-7 appears to be an effective and well-tolerated combination topical for the management of age-related and environment-induced skin changes.
衰老受内在和外在因素影响，会导致皮肤出现明显变化，如干燥、表面粗糙和光泽度丧失。适当的皮肤护理可以减轻其中一些影响，局部联合产品通过互补机制提供支持。
测试GSYBS-7（Goop Beauty Youth-Boost Peptide Serum；Goop Inc.，加利福尼亚州圣莫尼卡）的疗效和安全性，这是一种局部后生元和植物联合血清，每天在面部皮肤使用两次，持续6周。
在这项纳入19名患者的初步研究中，主要疗效指标是42天时全球排名量表（GRS）的改善情况。一项12分的患者满意度调查以及该血清对剥脱性激光治疗后愈合的影响分别作为次要和探索性指标。
早在第7天就观察到所有GRS领域有统计学意义的改善，直至第42天仍持续改善。脱水（1.8；95%CI，1.5 - 2.2）、可见毛孔（1.6；95%CI，1.3 - 2.0）、表面粗糙度（1.6；95%CI，1.3 - 1.9）、失衡（1.3；95%CI，0.9 - 1.7）、静态皱纹（1.3；95%CI，0.9 - 1.6）、色素沉着（1.3；95%CI，1.0 - 1.5）和血管状况（1.2；95%CI，0.8 - 1.5）均有超过1分的改善。独立的照片评估和患者满意度调查证实了这些发现。在第42天，94.4%的患者对结果非常满意，88.9%的患者会向家人和朋友推荐GSYBS-7。未报告不良事件，100%的患者表示GSYBS-7足够温和，适合日常使用。
GSYBS-7似乎是一种有效且耐受性良好的局部联合产品，可用于管理与年龄相关和环境引起的皮肤变化。
