Sadkovaia R M, Zin'kovskaia T M, Golubev A D
Farmakol Toksikol. 1986 Sep-Oct;49(5):90-2.
The effect of corinfar on the blood plasma Ca2+ content and oxyhemoglobin dissociation curve was studied in 52 patients with ischemic heart disease. The drug was administered in a dose of 60 mg/day and to 5 patients in a dose of 90 mg/day for 2 weeks. A complete disappearance of angina attacks and ECG normalization were observed in 37 patients, a good effect was noted in 30 patients and no effect was seen in 13 patients. A significant decrease of Ca2+ content during treatment was noted in patients with effort angina of mild and moderate degrees. Parallelism between Ca2+ content decrease and the drug efficacy was revealed.
在52例缺血性心脏病患者中研究了科里法（corinfar）对血浆Ca2+含量和氧合血红蛋白解离曲线的影响。药物剂量为60毫克/天，给5例患者的剂量为90毫克/天，持续2周。观察到37例患者心绞痛发作完全消失且心电图恢复正常，30例患者效果良好，13例患者无效果。轻度和中度劳力性心绞痛患者在治疗期间Ca2+含量显著降低。发现Ca2+含量降低与药物疗效之间存在平行关系。
