Stomatology Department, Zibo First Hospital, Zibo, Shandong Province, China.
Stomatology Department, Yidu Central Hospital of Weifang, Qingzhou, Shandong Province, China.
J Oral Pathol Med. 2023 Nov;52(10):886-894. doi: 10.1111/jop.13479. Epub 2023 Sep 13.
Oral squamous cell carcinoma is the most common phenotype in pathology, which accounts for 80% of all oral cancers. The therapeutic methods of oral squamous cell carcinoma include surgical excision, chemotherapy, and radiotherapy. Whereas, the high recurrence rate and poor prognosis lead to a 5-year survival rate less than 50%. In order to explore more therapeutic strategies of oral squamous cell carcinoma, the relevant risk factors, mechanisms, and diagnostics are widely detected. The various exosome-mediated biological effects on the development of oral squamous cell carcinoma have drawn lots of attention. Exosomes, a kind of extracellular vesicles secreted from host cells and transferred to other cells, show great potential in the regulations of tumorigenesis, progression, and metastasis on oral squamous cell carcinoma. Moreover, some studies reported that the exosomes could interact with tumor microenvironment and be applied to diagnosis or therapy of oral squamous cell carcinoma. In this work, we will summarize the frontier studies of exosomes in the tumor growth, tumor-associated angiogenesis, invasion, and metastasis of oral squamous cell carcinoma, and then probe the current biological functions and applications of exosomes and exosome-derived materials for the therapeutic strategies of oral squamous cell carcinoma, which would help us to update the understanding of exosomes in oral squamous cell carcinoma.
口腔鳞状细胞癌是病理上最常见的表型，占所有口腔癌的 80%。口腔鳞状细胞癌的治疗方法包括手术切除、化疗和放疗。然而，高复发率和预后不良导致 5 年生存率低于 50%。为了探索更多治疗口腔鳞状细胞癌的策略，广泛检测了相关的风险因素、机制和诊断方法。各种外泌体介导的生物学效应对口腔鳞状细胞癌的发展引起了广泛关注。外泌体是宿主细胞分泌并转移到其他细胞的一种细胞外囊泡，在外泌体在口腔鳞状细胞癌的肿瘤发生、进展和转移中的调控方面具有巨大的潜力。此外，一些研究报道外泌体可以与肿瘤微环境相互作用，并应用于口腔鳞状细胞癌的诊断或治疗。在这项工作中，我们将总结外泌体在口腔鳞状细胞癌肿瘤生长、肿瘤相关血管生成、侵袭和转移中的前沿研究，并探讨外泌体及其衍生材料的当前生物学功能和应用，以探索治疗口腔鳞状细胞癌的策略，这将有助于我们更新对外泌体在口腔鳞状细胞癌中的认识。
