School of International Education, Shanxi Medical University, Taiyuan, 030001, China.
School of Basic Medicine, Shanxi Medical University, Taiyuan, 030001, China.
Regen Med. 2023 Oct;18(10):795-807. doi: 10.2217/rme-2023-0089. Epub 2023 Sep 13.
Research has shown that the therapeutic effect of mesenchymal stem cells (MSCs) is partially due to its secreted factors as opposed to the implantation of the cells into the treated tissue or tissue replacement. MSC secretome, especially in the form of conditioned medium (MSC-CM) is now being explored as an alternative to MSCs transplantation. Despite the observed benefits of MSC-CM, only a few clinical trials have evaluated it and other secretome components in the treatment of eye diseases. This review provides insight into the potential therapeutic use of MSC-CM in eye conditions, such as corneal diseases, dry eye, glaucoma, retinal diseases and uveitis. We discuss the current evidence, some limitations, and the progress that remains to be achieved before clinical translation becomes possible.
研究表明，间充质干细胞（MSCs）的治疗效果部分归因于其分泌的因子，而不是将细胞植入治疗组织或组织替代物中。MSC 分泌组，特别是以条件培养基（MSC-CM）的形式，目前正被探索作为 MSC 移植的替代物。尽管观察到 MSC-CM 有好处，但只有少数临床试验评估了它和其他分泌组成分在眼部疾病的治疗中的作用。这篇综述提供了对 MSC-CM 在眼部疾病（如角膜疾病、干眼症、青光眼、视网膜疾病和葡萄膜炎）治疗中的潜在治疗用途的深入了解。我们讨论了目前的证据、一些局限性，以及在临床转化成为可能之前仍需取得的进展。
