Key Lab for Special Functional Materials, Ministry of Education, National & Local Joint Engineering Research Center for High-efficiency Display and Lighting Technology, School of Materials Science and Engineering, and Collaborative Innovation Center of Nano Functional Materials and Applications, Henan University, Kaifeng, 475004, China.
Helmholtz-Zentrum Berlin für Materialien und Energie, Kekuléstraße 5, 12489, Berlin, Germany.
Adv Mater. 2024 Jan;36(2):e2306860. doi: 10.1002/adma.202306860. Epub 2023 Nov 23.
Halide perovskites are crystalline semiconductors with exceptional optoelectronic properties, rapidly developing toward large-scale applications. Lead (II) (Pb ) is the core element used to prepare halide perovskites. Pb can displace key 2+ elements, including calcium, zinc and iron, that regulate vital physiological functions. Sn can replace Pb within the perovskite structure and, if accidentally dispersed in the environment, it readily oxidizes to Sn , which is compatible with physiological functions and thus potentially safe. The 3+ salt bismuth (III) (Bi ) is also potentially safe for the same reason and useful to prepare double perovskites. Here, this work studies the biotoxicity of Pb, Sn, and Bi perovskites in mice for the first time. This work analyses histopathology and growth of mice directly exposed to perovskites and investigate the development of their offspring generation. This study provides the screening of organs and key physiological functions targeted by perovskite exposure to design specific studies in mammalians.
卤化物钙钛矿是具有优异光电性能的晶体半导体，正在迅速向大规模应用发展。铅（II）（Pb）是用于制备卤化物钙钛矿的核心元素。Pb 可以取代关键的 2+元素，包括钙、锌和铁，这些元素调节重要的生理功能。Sn 可以在钙钛矿结构中取代 Pb，如果意外分散在环境中，它很容易氧化为 Sn4+，与生理功能兼容，因此具有潜在的安全性。同样出于这个原因，3+盐三价铋（III）（Bi）也具有潜在的安全性，并且可用于制备双钙钛矿。在这里，这项工作首次研究了 Pb、Sn 和 Bi 钙钛矿在小鼠中的生物毒性。这项工作分析了直接暴露于钙钛矿的小鼠的组织病理学和生长情况，并研究了它们后代的发育情况。这项研究提供了暴露于钙钛矿的器官和关键生理功能的筛选，以设计在哺乳动物中进行的特定研究。
