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利用数据科学和新技术制定并实施重症监护中的精准医疗策略。

Leveraging Data Science and Novel Technologies to Develop and Implement Precision Medicine Strategies in Critical Care.

机构信息

Department of Pediatrics, Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.

Department of Medicine, Emory University, 100 Woodruff Circle, Atlanta, GA 30322, USA.

出版信息

Crit Care Clin. 2023 Oct;39(4):627-646. doi: 10.1016/j.ccc.2023.03.002. Epub 2023 Apr 7.

Abstract

Precision medicine aims to identify treatments that are most likely to result in favorable outcomes for subgroups of patients with similar clinical and biological characteristics. The gaps for the development and implementation of precision medicine strategies in the critical care setting are many, but the advent of data science and multi-omics approaches, combined with the rich data ecosystem in the intensive care unit, offer unprecedented opportunities to realize the promise of precision critical care. In this article, the authors review the data-driven and technology-based approaches being leveraged to discover and implement precision medicine strategies in the critical care setting.

摘要

精准医学旨在识别最有可能使具有相似临床和生物学特征的亚组患者获得有利结果的治疗方法。在重症监护环境中开发和实施精准医学策略存在许多差距,但数据科学和多组学方法的出现,以及重症监护病房丰富的数据生态系统,为实现精准重症监护的承诺提供了前所未有的机会。在本文中,作者回顾了正在利用的数据驱动和基于技术的方法来发现和实施重症监护环境中的精准医学策略。

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