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选定氨基糖苷类抗生素对人血清白蛋白抗氧化活性的影响：光谱学和量热法比较研究。

The effect of selected aminoglycoside antibiotics on human serum albumin antioxidant activity: a spectroscopic and calorimetric comparative study.

机构信息

Department of Physical Pharmacy, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, 40-055, Katowice, Poland.

出版信息

Pharmacol Rep. 2023 Oct;75(5):1276-1290. doi: 10.1007/s43440-023-00529-6. Epub 2023 Sep 13.

DOI:10.1007/s43440-023-00529-6
PMID:37704832
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10539444/
Abstract

BACKGROUND

Human serum albumin (HSA) is a valuable component of non-enzymatic and endogenous antioxidant mechanisms. The antioxidant activity of HSA can be modulated by ligands, including drugs. Although this is a central topic in the field of oxidation, there is still a lack of information about the protection against the effects of elevated free radical levels.

METHODS

The aim of this study was to investigate the antioxidant activity of kanamycin (KAN) and neomycin (NEO) and their effect on the antioxidant potential of HSA using spectroscopic and microcalorimetric techniques.

RESULTS

Despite the fact that kanamycin and neomycin interact with HSA, no changes in the secondary structure of the protein have been observed. The analysis of the aminoglycoside antibiotics showed their low antioxidant activity and a synergistic effect of the interaction, probably due to the influence of ligands (KAN, NEO) on the availability of HSA amino acid residues functional groups, such as the free thiol group (Cys-34).

CONCLUSIONS

Based on the spectroscopic and microcalorimetric data, both KAN and NEO can be considered modulators of the HSA antioxidant activity.

摘要

背景

人血清白蛋白（HSA）是无酶和内源性抗氧化机制的重要组成部分。HSA 的抗氧化活性可以通过配体（包括药物）来调节。尽管这是氧化领域的一个核心话题，但关于其对抗自由基水平升高的影响的信息仍然缺乏。

方法

本研究旨在使用光谱和微量热技术研究卡那霉素（KAN）和新霉素（NEO）的抗氧化活性及其对 HSA 抗氧化能力的影响。

结果

尽管卡那霉素和新霉素与 HSA 相互作用，但未观察到蛋白质二级结构发生变化。对氨基糖苷类抗生素的分析表明，它们的抗氧化活性较低，并且相互作用具有协同效应，这可能是由于配体（KAN、NEO）影响 HSA 氨基酸残基功能基团的可用性，例如游离巯基（Cys-34）。

结论

根据光谱和微量热数据，卡那霉素和新霉素均可被视为 HSA 抗氧化活性的调节剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a25/10539444/631132201abf/43440_2023_529_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a25/10539444/ce27ca8d43fa/43440_2023_529_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a25/10539444/7b61fa5d518b/43440_2023_529_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a25/10539444/78ac54e0a165/43440_2023_529_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a25/10539444/fb2692d38734/43440_2023_529_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a25/10539444/4e7114a3d299/43440_2023_529_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a25/10539444/631132201abf/43440_2023_529_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a25/10539444/ce27ca8d43fa/43440_2023_529_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a25/10539444/7b61fa5d518b/43440_2023_529_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a25/10539444/78ac54e0a165/43440_2023_529_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a25/10539444/fb2692d38734/43440_2023_529_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a25/10539444/4e7114a3d299/43440_2023_529_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a25/10539444/631132201abf/43440_2023_529_Fig6_HTML.jpg

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