Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
Key Laboratory of Basic and Translational Research on Immune-Mediated Skin Diseases, Chinese Academy of Medical Sciences, Nanjing, China.
Br J Dermatol. 2023 Dec 20;190(1):55-61. doi: 10.1093/bjd/ljad339.
Atopic dermatitis (AD) is the leading cause of the global burden from skin disease; no study has provided global and country-specific epidemiological estimates of AD.
To quantify global, regional and country-specific estimates of the epidemiology of AD.
A comprehensive search for epidemiological studies in AD was conducted in four electronic databases (PubMed, Embase, Web of Science and China National Knowledge Infrastructure). A Bayesian hierarchical linear mixed model was constructed to calculate epidemiological estimates of AD considering the heterogeneity of regions, countries, type of diagnoses and age strata.
In total, 344 studies met the inclusion criteria. Incidence varied substantially with the location and age of the surveyed participants. The global prevalence of AD and the population affected by AD were estimated to be 2.6% [95% uncertainty interval (UI) 1.9-3.5] and 204.05 million people, respectively. Around 101.27 million adults and 102.78 million children worldwide have AD, corresponding to prevalence rates of 2.0% (95% UI 1.4-2.6) and 4.0% (95% UI 2.8-5.3), respectively. Females were more likely to suffer from AD than males: the global prevalence of AD in females was 2.8% (95% UI 2.0-3.7%) and affected 108.29 million people, while in males the corresponding estimates were 2.4% (95% UI 1.7-3.3%) and 95.76 million people.
Epidemiological AD data are lacking in 41.5% of countries worldwide. The epidemiology of AD varies substantially with age and sex and is distributed unequally across geographical regions.
特应性皮炎（AD）是全球皮肤疾病负担的主要原因；尚无研究提供 AD 的全球和国家特定的流行病学估计。
量化 AD 的全球、区域和国家特定的流行病学估计。
在四个电子数据库（PubMed、Embase、Web of Science 和中国国家知识基础设施）中对 AD 的流行病学研究进行了全面搜索。考虑到区域、国家、诊断类型和年龄层的异质性，构建了贝叶斯分层线性混合模型来计算 AD 的流行病学估计。
共有 344 项研究符合纳入标准。发病率因调查参与者的位置和年龄而异。AD 的全球患病率和受 AD 影响的人群估计分别为 2.6%（95%置信区间 1.9-3.5）和 204.05 百万。全球约有 1.0127 亿成年人和 1.0278 亿儿童患有 AD，患病率分别为 2.0%（95%置信区间 1.4-2.6）和 4.0%（95%置信区间 2.8-5.3）。女性比男性更容易患 AD：全球女性 AD 的患病率为 2.8%（95%置信区间 2.0-3.7%），受影响人数为 1.0829 百万，而男性的相应估计值为 2.4%（95%置信区间 1.7-3.3%）和 95.76 百万。
全球有 41.5%的国家缺乏 AD 的流行病学数据。AD 的流行病学随年龄和性别有很大差异，在地理区域分布不均。
