Zhang Dongyun, Zhang Yixuan, Luo Yanchun, Qi Erpeng, Yu Jie, Liang Ping
Department of Interventional Ultrasound, Fifth Medical Center of Chinese PLA General Hospital Beijing China
Nanoscale Adv. 2023 Aug 1;5(18):4892-4900. doi: 10.1039/d2na00880g. eCollection 2023 Sep 12.
Microwave ablation (MWA) is a promising minimally invasive therapy for hepatocellular carcinoma (HCC). However, the efficiency of MWA in treating HCC is evidently limited by the incomplete ablation of large tumors and tumors in high-risk locations. Here we designed an iron-based metal-organic framework nanomedicine (PFP-Apa-MOF) by loading perfluoropentane (PFP) and apatinib (Apa). After being absorbed by HCC, iron could induce ferroptosis. PFP could be activated into bubbles and act as an ultrasound agent for detecting the ablation margin. As an effective antiangiogenic drug, Apa could inhibit tumor residual growth after MWA. The high efficiency of PFP-Apa-MOF was fully demonstrated and . The results showed that MWA combined with PFP-Apa-MOF clearly enhanced the ablation efficiency, leading to apparent tumor inhibition, and increased tumor apoptosis and lipid peroxide. PFP-Apa-MOF could play a valuable role in enhancing MWA to achieve better therapeutic efficacy in HCC.
微波消融（MWA）是一种很有前景的肝细胞癌（HCC）微创治疗方法。然而，MWA治疗HCC的效率明显受到大肿瘤及高危部位肿瘤不完全消融的限制。在此，我们通过负载全氟戊烷（PFP）和阿帕替尼（Apa）设计了一种铁基金属有机框架纳米药物（PFP-Apa-MOF）。被HCC吸收后，铁可诱导铁死亡。PFP可被激活形成气泡并作为检测消融边缘的超声剂。作为一种有效的抗血管生成药物，Apa可抑制MWA后肿瘤的残留生长。PFP-Apa-MOF的高效性得到了充分证明。结果表明，MWA联合PFP-Apa-MOF明显提高了消融效率，导致明显的肿瘤抑制，并增加了肿瘤凋亡和脂质过氧化。PFP-Apa-MOF在增强MWA以实现更好的HCC治疗效果方面可发挥重要作用。
