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在铁/铜嵌入纳米催化底物上快速合成[1,2,3]-三唑衍生物。

Fast synthesis of [1,2,3]-triazole derivatives on a Fe/Cu-embedded nano-catalytic substrate.

作者信息

Khaleghi Nima, Mojtabapour Zahrasadat, Rashvandi Zahra, Mohammadi Adibeh, Forouzandeh-Malati Mohadeseh, Ganjali Fatemeh, Zarei-Shokat Simindokht, Kashtiaray Amir, Taheri-Ledari Reza, Maleki Ali

机构信息

Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology Tehran 16846-13114 Iran

出版信息

Nanoscale Adv. 2023 Aug 29;5(18):4911-4924. doi: 10.1039/d3na00326d. eCollection 2023 Sep 12.

DOI:10.1039/d3na00326d
PMID:37705809
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10496887/
Abstract

Triazoles are biologically important compounds that play a crucial role in biomedical applications. In this study, we present an innovative and eco-friendly nanocatalyst system for synthesizing compounds the click reaction. The system is composed of Arabic gum (AG), iron oxide magnetic nanoparticles (FeO MNPs), (3-chloropropyl) trimethoxysilane (CPTMS), 2-aminopyridine (AP), and Cu(i) ions. Using AP as an anchor for Cu(i) ions and FeO MNPs allows facile separation using an external magnet. The hydrophilic nature of the FeO@AG/AP-Cu(i) nanocomposite makes it highly efficient in water as a green solvent. The highest reaction efficiency (95.0%) was achieved in HO solvent with 50.0 mg of nanocatalyst for 60 min at room temperature. The reaction yield remained consistent for six runs, demonstrating the stability and effectiveness of the catalyst.

摘要

三唑是具有重要生物学意义的化合物，在生物医学应用中发挥着关键作用。在本研究中，我们提出了一种用于通过点击反应合成化合物的创新且环保的纳米催化剂体系。该体系由阿拉伯胶（AG）、氧化铁磁性纳米颗粒（FeO MNPs）、（3-氯丙基）三甲氧基硅烷（CPTMS）、2-氨基吡啶（AP）和Cu(i)离子组成。使用AP作为Cu(i)离子和FeO MNPs的锚定剂，可以通过外部磁铁轻松分离。FeO@AG/AP-Cu(i)纳米复合材料的亲水性使其在作为绿色溶剂的水中具有高效性。在室温下，使用50.0毫克纳米催化剂在HO溶剂中反应60分钟，实现了最高反应效率（95.0%）。该反应产率在六次运行中保持一致，证明了催化剂的稳定性和有效性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2af/10496887/08a0672a112d/d3na00326d-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2af/10496887/01e0d50fe0b7/d3na00326d-s1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2af/10496887/085118182c24/d3na00326d-f4.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2af/10496887/6db7dafba892/d3na00326d-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2af/10496887/08a0672a112d/d3na00326d-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2af/10496887/01e0d50fe0b7/d3na00326d-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2af/10496887/95fa89b7e6f9/d3na00326d-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2af/10496887/d76a0390a55d/d3na00326d-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2af/10496887/629619e8414a/d3na00326d-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2af/10496887/085118182c24/d3na00326d-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2af/10496887/f3ed8e2ae06a/d3na00326d-s2.jpg
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