文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

一种用于在卵巢癌细胞中选择性递送 Ca(OH) 和紫杉醇的磁性抗体偶联纳米系统。

A magnetic antibody-conjugated nano-system for selective delivery of Ca(OH) and taxotere in ovarian cancer cells.

机构信息

Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran.

出版信息

Commun Biol. 2022 Sep 21;5(1):995. doi: 10.1038/s42003-022-03966-w.

DOI:10.1038/s42003-022-03966-w
PMID:36130999
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9492675/
Abstract

An efficient strategy for cancer therapy is presented, in which a tumor mass is initially pretreated with calcium hydroxide, then treated with Taxotere (TXT). In this regard, an advanced delivery system based on iron oxide nanoparticles has been designed. The surface of nanoparticles was functionalized with sortilin (SORT-1, a human IgG1 monoclonal antibody) that specifically encodes caov-4 ovarian cancerous cells. Plasmonic heating of the incorporated gold nanoparticles in polyvinyl alcohol (PVA) has been exploited to control the release process of TXT. The in vitro, ex vivo and in vivo experiments have exhibited high efficacy of a seven-day pretreatment by Ca(OH) plus 14 days treatment program by Ca(OH)@FeO/PVA/Au-SORT nano-therapeutics, where more penetration ratio resulted in tumor growth inhibition by ca. 78.3%. As a result, due to showing high values of the anti-tumor properties and biosafety, the presented pretreatment strategy is suggested for more effective treatment on the aged tumors.

摘要

提出了一种用于癌症治疗的有效策略，该策略首先用氢氧化钙预处理肿瘤块，然后用 Taxotere（TXT）进行处理。在这方面，设计了一种基于氧化铁纳米粒子的先进递药系统。纳米粒子的表面用转铁蛋白（SORT-1，一种人 IgG1 单克隆抗体）功能化，该抗体特异性编码 caov-4 卵巢癌细胞。利用聚已醇（PVA）中掺入的金纳米粒子的等离子体加热来控制 TXT 的释放过程。体外、离体和体内实验都显示出 Ca(OH)预处理 7 天和 Ca(OH)@FeO/PVA/Au-SORT 纳米治疗 14 天的治疗方案具有很高的疗效，其中渗透比增加导致肿瘤生长抑制约 78.3%。结果，由于表现出高抗肿瘤特性和生物安全性，因此建议采用所提出的预处理策略对老年肿瘤进行更有效的治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e92/9492675/8895a61f6040/42003_2022_3966_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e92/9492675/0e3259f6eea2/42003_2022_3966_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e92/9492675/800562a1bfbc/42003_2022_3966_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e92/9492675/26effdcbaad2/42003_2022_3966_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e92/9492675/7ef49edc10ac/42003_2022_3966_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e92/9492675/db8d35e0c977/42003_2022_3966_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e92/9492675/5a9f7d86a2b0/42003_2022_3966_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e92/9492675/6620572613e0/42003_2022_3966_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e92/9492675/e62795b34a5c/42003_2022_3966_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e92/9492675/8895a61f6040/42003_2022_3966_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e92/9492675/0e3259f6eea2/42003_2022_3966_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e92/9492675/800562a1bfbc/42003_2022_3966_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e92/9492675/26effdcbaad2/42003_2022_3966_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e92/9492675/7ef49edc10ac/42003_2022_3966_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e92/9492675/db8d35e0c977/42003_2022_3966_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e92/9492675/5a9f7d86a2b0/42003_2022_3966_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e92/9492675/6620572613e0/42003_2022_3966_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e92/9492675/e62795b34a5c/42003_2022_3966_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e92/9492675/8895a61f6040/42003_2022_3966_Fig9_HTML.jpg

相似文献

[1]
A magnetic antibody-conjugated nano-system for selective delivery of Ca(OH) and taxotere in ovarian cancer cells.

Commun Biol. 2022-9-21

[2]
Multi-Stimuli Nanocomposite Therapeutic: Docetaxel Targeted Delivery and Synergies in Treatment of Human Breast Cancer Tumor.

Small. 2020-10

[3]
Magnetic Fe₃ O ₄ nanoparticles grafted with single-chain antibody (scFv) and docetaxel loaded β-cyclodextrin potential for ovarian cancer dual-targeting therapy.

Mater Sci Eng C Mater Biol Appl. 2014-9

[4]
Sodium alginate-polyvinyl alcohol-bovin serum albumin coated FeO nanoparticles as anticancer drug delivery vehicle: Doxorubicin loading and in vitro release study and cytotoxicity to HepG2 and L02 cells.

Mater Sci Eng C Mater Biol Appl. 2017-10-1

[5]
Cefixime-Containing Silica Nanoseeds Coated by a Hybrid PVA-Gold Network with a Cys-Arg Dipeptide Conjugation: Enhanced Antimicrobial and Drug Release Properties.

Langmuir. 2022-1-11

[6]
Chitosan/Gold Hybrid Nanoparticles Enriched Electrospun PVA Nanofibrous Mats for the Topical Delivery of L. Extract: Synthesis, Characterization, Biocompatibility and Antibacterial Properties.

Int J Nanomedicine. 2021

[7]
Paper based immunosensing of ovarian cancer tumor protein CA 125 using novel nano-ink: A new platform for efficient diagnosis of cancer and biomedical analysis using microfluidic paper-based analytical devices (μPAD).

Int J Biol Macromol. 2019-7-18

[8]
Electrochemical immunosensor based on ZnO nanorods-Au nanoparticles nanohybrids for ovarian cancer antigen CA-125 detection.

Mater Sci Eng C Mater Biol Appl. 2017-7-1

[9]
Intra-arterial delivery of superparamagnetic iron-oxide nanoshell and polyvinyl alcohol based chemoembolization system for the treatment of liver tumor.

Discov Med. 2017-1

[10]
pH-dependent swelling and antibiotic release from citric acid crosslinked poly(vinyl alcohol) (PVA)/nano silver hydrogels.

Colloids Surf B Biointerfaces. 2019-12-24

引用本文的文献

[1]
Future theranostic strategies: emerging ovarian cancer biomarkers to bridge the gap between diagnosis and treatment.

Front Drug Deliv. 2024-2-1

[2]
Finite Element Simulation of Interstitial-Lymphatic Fluid Flow and Nanodrug Transport in a Solid Tumor: An Intratumoral Injection Approach.

BME Front. 2025-6-6

[3]
Cellular and Molecular Effects of Magnetic Fields.

Int J Mol Sci. 2024-8-17

[4]
The therapeutic effect and MR molecular imaging of FA-PEG-FePt/DDP nanoliposomes in AMF on ovarian cancer.

Int J Nanomedicine. 2024

[5]
The Application of Nanotechnological Therapeutic Platforms against Gynecological Cancers.

Curr Pharm Des. 2024

[6]
Advances in Brain Tumor Therapy Based on the Magnetic Nanoparticles.

Int J Nanomedicine. 2023

[7]
Plasmonic porous micro- and nano-materials based on Au/Ag nanostructures developed for photothermal cancer therapy: challenges in clinicalization.

Nanoscale Adv. 2023-11-27

[8]
Fast synthesis of [1,2,3]-triazole derivatives on a Fe/Cu-embedded nano-catalytic substrate.

Nanoscale Adv. 2023-8-29

[9]
Nanocargos designed with synthetic and natural polymers for ovarian cancer management.

Naunyn Schmiedebergs Arch Pharmacol. 2023-12

[10]
A Review of Advanced Multifunctional Magnetic Nanostructures for Cancer Diagnosis and Therapy Integrated into an Artificial Intelligence Approach.

Pharmaceutics. 2023-3-7

本文引用的文献

[1]
Nanoscale bioconjugates: A review of the structural attributes of drug-loaded nanocarrier conjugates for selective cancer therapy.

Heliyon. 2022-6-2

[2]
Cefixime-Containing Silica Nanoseeds Coated by a Hybrid PVA-Gold Network with a Cys-Arg Dipeptide Conjugation: Enhanced Antimicrobial and Drug Release Properties.

Langmuir. 2022-1-11

[3]
Plasmonic photothermal release of docetaxel by gold nanoparticles incorporated onto halloysite nanotubes with conjugated 2D8-E3 antibodies for selective cancer therapy.

J Nanobiotechnology. 2021-8-11

[4]
Nanocrystal-Loaded Micelles for the Enhanced In Vivo Circulation of Docetaxel.

Molecules. 2021-7-24

[5]
Antibody-Drug Conjugates-A Tutorial Review.

Molecules. 2021-5-15

[6]
Multifunctional Magneto-Plasmonic FeO/Au Nanocomposites: Approaching Magnetophoretically-Enhanced Photothermal Therapy.

Nanomaterials (Basel). 2021-4-25

[7]
Understanding and advancement in gold nanoparticle targeted photothermal therapy of cancer.

Biochim Biophys Acta Rev Cancer. 2021-4

[8]
Dual RNA 3'-end processing of H2A.X messenger RNA maintains DNA damage repair throughout the cell cycle.

Nat Commun. 2021-1-13

[9]
The NF-kB and Collagen Type 1 Expression in Dental Pulp after Treated Calcium Hydroxide Combined with Propolis.

Eur J Dent. 2021-2

[10]
Fabrication and Characterization of Nanocomposite Flexible Membranes of PVA and FeO.

Molecules. 2020-12-29

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索