Zhao Meng-Chuan, Wen Chan, Sun Ling, Duan Su-Xia, Zang Ke-Xin, Wang Le, Cui Xiao-Wei
Department of Laborotory Medicine, Children's Hospital of Hebei Province, Shijiazhuang, People's Republic of China.
Department of Medical, Children's Hospital of Hebei Province, Shijiazhuang, People's Republic of China.
Risk Manag Healthc Policy. 2023 Sep 8;16:1801-1807. doi: 10.2147/RMHP.S423077. eCollection 2023.
This study aimed to assess the impact of the COVID-19 pandemic on the prevalence and clinical characteristics of seasonal human coronavirus (HCoV) infections among children hospitalized in Hebei, China.
We examined nasopharyngeal aspirate (NPA) specimens for seasonal HCoVs from January 2018 to December 2021, at the Children's Hospital of Hebei Province. We used a GeXP-based multiplex reverse transcription PCR assay for the detection of 11 common respiratory viruses (including seasonal HCoVs), chlamydia, and . The demographic and clinical characteristics of children who tested positive for seasonal HCoVs were recorded and analyzed.
A total of 377 (1.96%) of the 19,248 specimens from 2018 to 2019 and 263 (1.96%) of the 13,426 specimens from 2020 to 2021 exhibited seasonal HCoVs. Compared to 2018 and 2019, the positive rate of seasonal HCoVs was lower from January to July of 2020 and increased beginning in August 2020, peaking in the autumn and winter. In 2020-2021, nasal blockage and swollen adenoids were detected more frequently in children who tested positive for seasonal HCoVs. During 2018-2019, however, the duration of fever was significantly longer, and cough and dyspnea were more prominent among children who had fallen ill. In addition, seasonal HCoV-positive patients in 2018-2019 were more likely to experience complications, had a higher risk of severe community-acquired pneumonia (CAP), and had a tendency to require a longer hospital stay than patients in 2020-2021.
According to our findings, there were significant changes in the epidemiology of seasonal HCoVs in Hebei, China during the COVID-19 pandemic, and children infected with seasonal HCoVs usually experienced milder clinical symptoms during the pandemic than before it.
本研究旨在评估新型冠状病毒肺炎（COVID-19）大流行对中国河北省住院儿童季节性人冠状病毒（HCoV）感染的患病率及临床特征的影响。
我们于2018年1月至2021年12月在河北省儿童医院检测了鼻咽抽吸物（NPA）标本中的季节性HCoV。我们使用基于GeXP的多重逆转录聚合酶链反应（PCR）检测法来检测11种常见呼吸道病毒（包括季节性HCoV）、衣原体及……。记录并分析了季节性HCoV检测呈阳性儿童的人口统计学和临床特征。
2018年至2019年的19248份标本中有377份（1.96%），2020年至2021年的13426份标本中有263份（1.96%）检测出季节性HCoV。与2018年和2019年相比，2020年1月至7月季节性HCoV的阳性率较低，2020年8月开始上升，在秋冬达到峰值。2020 - 2021年，季节性HCoV检测呈阳性的儿童中鼻塞和腺样体肿大的检出频率更高。然而，在2018 - 2019年期间，发热持续时间明显更长，患病儿童中咳嗽和呼吸困难更为突出。此外，2018 - 2019年季节性HCoV阳性患者比2020 - 2021年的患者更易出现并发症，发生重症社区获得性肺炎（CAP）的风险更高，且住院时间往往更长。
根据我们的研究结果，在COVID-19大流行期间，中国河北省季节性HCoV的流行病学发生了显著变化，感染季节性HCoV的儿童在大流行期间的临床症状通常比之前更为轻微。
