Service de Parasitologie-Mycologie, 3IHP, CHU Clermont-Ferrand, Clermont-Ferrand, France.
National Reference Center for Cryptosporidiosis, Microsporidia and Other Digestive Protozoa, Clermont-Ferrand, France.
Emerg Microbes Infect. 2023 Dec;12(2):2258997. doi: 10.1080/22221751.2023.2258997. Epub 2023 Sep 14.
Intestinal microsporidiosis is most often caused by , and to a lesser extent by species of the genus . Until now, was not clearly known to induce disease restricted to the intestine, or rarely in HIV subjects or in tropical countries. We report here 11 cases of delineated intestinal microsporidioses due to diagnosed in France in non-HIV patients. Briefly, all patients were immunocompromised. They all suffered from diarrhoea, associated in nearly 50% of cases with weight loss. Concerning treatment, 5/11 patients had a discontinuation or a decrease of their immunosuppressive therapy, and 4/11 received albendazole. All patients recovered. Five different genotypes were identified based on the rRNA ITS sequence.
肠微孢子虫病主要由 引起，在较小程度上由属的种引起。到目前为止，尚未明确 引起仅限于肠道的疾病，或很少在 HIV 患者或热带国家中引起。我们在此报告 11 例在法国诊断出的非 HIV 患者的明确的肠微孢子虫病。简而言之，所有患者均免疫功能低下。他们均患有腹泻，近 50％的病例伴有体重减轻。关于治疗，11 例中有 5 例停止或减少免疫抑制治疗，4 例接受了阿苯达唑治疗。所有患者均康复。基于 rRNA ITS 序列鉴定了 5 种不同的基因型。
