Morales Carolina Salvador, Grodzinski Piotr
Nanodelivery Systems and Devices Branch, Cancer Imaging Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Rockville, Maryland, USA.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2024 Jan-Feb;16(1):e1927. doi: 10.1002/wnan.1927. Epub 2023 Sep 14.
The efforts to use novel nanotechnologies in medicine and cancer have been widespread. In order to understand better the focus areas of cancer nanomedicine research to date, we conducted a survey of nanomedicine developmental and clinical research in conjunction with treatment of various cancers. The survey has been performed based on number of publications, rate of citations, entry into clinical trials, and funding rates by the National Cancer Institute. Our survey indicates that breast and brain cancers are the most and one of the least studied by nanotechnology researchers, respectively. Breast cancer nano-therapies seem to also be most likely to achieve clinical translation as the number of publications produced, amount of funding, total citations, and clinical trials (active and completed) are the highest when compared with research in other cancers. Brain cancer, despite its low survival, has capture much less attention of nanomedicine research community as survey indicated, although nanotechnology can offer novel approaches which can address brain cancer challenges. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease.
在医学和癌症领域应用新型纳米技术的努力已经十分广泛。为了更好地了解迄今为止癌症纳米医学研究的重点领域，我们结合各种癌症的治疗开展了一项纳米医学发展与临床研究调查。该调查是基于出版物数量、被引率、进入临床试验情况以及美国国立癌症研究所的资助率进行的。我们的调查表明，乳腺癌是纳米技术研究人员研究最多的癌症，而脑癌则是研究最少的癌症之一。乳腺癌纳米疗法似乎也最有可能实现临床转化，因为与其他癌症的研究相比，其产生的出版物数量、资金数额、总被引次数以及临床试验（正在进行和已完成的）数量都是最高的。尽管脑癌患者生存率低，但正如调查所示，它在纳米医学研究领域受到的关注要少得多，尽管纳米技术可以提供应对脑癌挑战的新方法。本文分类如下：治疗方法与药物发现>肿瘤疾病的纳米医学。
