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纳米光疗法:癌症治疗的良好前景。

Nano-phototherapy: Favorable prospects for cancer treatment.

作者信息

Merlin J P Jose, Crous Anine, Abrahamse Heidi

机构信息

Laser Research Centre, Faculty of Health Sciences, University of Johannesburg, Johannesburg, South Africa.

出版信息

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2024 Jan-Feb;16(1):e1930. doi: 10.1002/wnan.1930. Epub 2023 Sep 26.

DOI:10.1002/wnan.1930
PMID:37752098
Abstract

Nanotechnology-based phototherapies have drawn interest in the fight against cancer because of its noninvasiveness, high flexibility, and precision in terms of cancer targeting and drug delivery based on its surface properties and size. Phototherapy has made remarkable development in recent decades. Approaches to phototherapy, which utilize nanomaterials or nanotechnology have emerged to contribute to advances around nanotechnologies in medicine, particularly for cancers. A brief overviews of the development of photodynamic therapy as well as its mechanism in cancer treatment is provided. We emphasize the design of novel nanoparticles utilized in photodynamic therapy while summarizing the representative progress during the recent years. Finally, to forecast important future research in this area, we examine the viability and promise of photodynamic therapy systems based on nanoparticles in clinical anticancer treatment applications and briefly make mention of the elimination of all reactive metabolites pertaining to nano formulations inside living organisms providing insight into clinical mechanistic processes. Future developments and therapeutic prospects for photodynamic treatments are anticipated. Our viewpoints might encourage scientists to create more potent phototherapy-based cancer therapeutic modalities. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease.

摘要

基于纳米技术的光疗法因其非侵入性、高度灵活性以及基于其表面性质和尺寸在癌症靶向和药物递送方面的精准性,在抗癌斗争中引起了人们的关注。近几十年来,光疗法取得了显著进展。利用纳米材料或纳米技术的光疗法已出现,为医学领域纳米技术的进步做出了贡献,特别是在癌症治疗方面。本文简要概述了光动力疗法的发展及其在癌症治疗中的机制。我们在总结近年来代表性进展的同时,强调了用于光动力疗法的新型纳米颗粒的设计。最后,为预测该领域未来的重要研究方向,我们研究了基于纳米颗粒的光动力疗法系统在临床抗癌治疗应用中的可行性和前景,并简要提及了生物体内与纳米制剂相关的所有活性代谢物的消除,以深入了解临床机制过程。预计光动力治疗的未来发展和治疗前景广阔。我们的观点可能会鼓励科学家创造更有效的基于光疗法的癌症治疗方式。本文分类如下:治疗方法与药物发现>肿瘤疾病纳米医学。

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引用本文的文献

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Cancer Med. 2025 Aug;14(15):e71032. doi: 10.1002/cam4.71032.
2
Breaking the Resistance: Photodynamic Therapy in Cancer Stem Cell-Driven Tumorigenesis.突破抗性:光动力疗法在癌症干细胞驱动的肿瘤发生中的应用
Pharmaceutics. 2025 Apr 24;17(5):559. doi: 10.3390/pharmaceutics17050559.
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Mini Review On: The Roles of DNA Nanomaterials in Phototherapy.关于:DNA纳米材料在光疗中的作用的综述
Int J Nanomedicine. 2025 Feb 14;20:2021-2041. doi: 10.2147/IJN.S501471. eCollection 2025.
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Advancing Photodynamic Therapy with Nano-Conjugated Hypocrellin: Mechanisms and Clinical Applications.纳米缀合竹红菌素推进光动力疗法:机制与临床应用。
Int J Nanomedicine. 2024 Nov 1;19:11023-11038. doi: 10.2147/IJN.S486014. eCollection 2024.
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Combining Photodynamic Therapy and Targeted Drug Delivery Systems: Enhancing Mitochondrial Toxicity for Improved Cancer Outcomes.光动力疗法与靶向药物递送系统联合应用:增强线粒体毒性以改善癌症治疗效果。
Int J Mol Sci. 2024 Oct 8;25(19):10796. doi: 10.3390/ijms251910796.
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Biomimetic Ghost Nanomedicine-Based Optotheranostics for Cancer.仿生幽灵纳米医学癌症光热治疗一体化。
Nano Lett. 2024 Jul 10;24(27):8217-8231. doi: 10.1021/acs.nanolett.4c01534. Epub 2024 Jun 7.