Merlin J P Jose, Crous Anine, Abrahamse Heidi
Laser Research Centre, Faculty of Health Sciences, University of Johannesburg, Johannesburg, South Africa.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2024 Jan-Feb;16(1):e1930. doi: 10.1002/wnan.1930. Epub 2023 Sep 26.
Nanotechnology-based phototherapies have drawn interest in the fight against cancer because of its noninvasiveness, high flexibility, and precision in terms of cancer targeting and drug delivery based on its surface properties and size. Phototherapy has made remarkable development in recent decades. Approaches to phototherapy, which utilize nanomaterials or nanotechnology have emerged to contribute to advances around nanotechnologies in medicine, particularly for cancers. A brief overviews of the development of photodynamic therapy as well as its mechanism in cancer treatment is provided. We emphasize the design of novel nanoparticles utilized in photodynamic therapy while summarizing the representative progress during the recent years. Finally, to forecast important future research in this area, we examine the viability and promise of photodynamic therapy systems based on nanoparticles in clinical anticancer treatment applications and briefly make mention of the elimination of all reactive metabolites pertaining to nano formulations inside living organisms providing insight into clinical mechanistic processes. Future developments and therapeutic prospects for photodynamic treatments are anticipated. Our viewpoints might encourage scientists to create more potent phototherapy-based cancer therapeutic modalities. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease.
基于纳米技术的光疗法因其非侵入性、高度灵活性以及基于其表面性质和尺寸在癌症靶向和药物递送方面的精准性,在抗癌斗争中引起了人们的关注。近几十年来,光疗法取得了显著进展。利用纳米材料或纳米技术的光疗法已出现,为医学领域纳米技术的进步做出了贡献,特别是在癌症治疗方面。本文简要概述了光动力疗法的发展及其在癌症治疗中的机制。我们在总结近年来代表性进展的同时,强调了用于光动力疗法的新型纳米颗粒的设计。最后,为预测该领域未来的重要研究方向,我们研究了基于纳米颗粒的光动力疗法系统在临床抗癌治疗应用中的可行性和前景,并简要提及了生物体内与纳米制剂相关的所有活性代谢物的消除,以深入了解临床机制过程。预计光动力治疗的未来发展和治疗前景广阔。我们的观点可能会鼓励科学家创造更有效的基于光疗法的癌症治疗方式。本文分类如下:治疗方法与药物发现>肿瘤疾病纳米医学。