Zhang Jiawen, Zou Linjun, Li Qinglong, Wu Haifeng, Sun Zhonghao, Xu Xudong, Shi Leiling, Sun Zhaocui, Ma Guoxu
Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education; Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China.
Xinjiang Institute of Chinese and Ethnic Medicine, Urumqi 830002, China.
ACS Appl Bio Mater. 2023 Oct 16;6(10):3984-4001. doi: 10.1021/acsabm.3c00462. Epub 2023 Sep 14.
In the field of carbon nanomaterials, carbon dots (CDs) have become a preferable choice in biomedical applications. Based on the concept of green chemistry, CDs derived from traditional Chinese medicines (TCMs) have attracted extensive attention, including TCM charcoal drugs, TCM extracts, and TCM small molecules. The design and preparation of CDs from TCMs (TCMs-CDs) can improve the inherent characteristics of TCMs, such as solubility, particle size distribution, and so on. Compared with other precursor materials, TCMs-CDs have outstanding intrinsic bioactivities and potential pharmacological effects. However, the research of TCMs-CDs in biomedicine is not comprehensive, and their mechanisms have not been understood deeply either. In this review, we will provide concise insights into the recent development of TCMs-CDs, with a major focus on their preparation, formation, precursors, and bioactivities. Then we will discuss the perfect transformation from TCMs to TCMs-CDs. Finally, we discuss the opportunities and challenges for the application of TCMs-CDs in clinical treatment.
在碳纳米材料领域，碳点（CDs）已成为生物医学应用中的首选。基于绿色化学概念，源自中药（TCMs）的碳点引起了广泛关注，包括中药炭药、中药提取物和中药小分子。由中药制备碳点（TCMs-CDs）的设计与制备可以改善中药的固有特性，如溶解度、粒度分布等。与其他前驱体材料相比，TCMs-CDs具有出色的内在生物活性和潜在药理作用。然而，TCMs-CDs在生物医学方面的研究并不全面，其作用机制也尚未被深入理解。在本综述中，我们将简要介绍TCMs-CDs的最新进展，主要关注其制备、形成、前驱体和生物活性。然后我们将讨论从中药到TCMs-CDs的完美转变。最后，我们探讨TCMs-CDs在临床治疗应用中的机遇与挑战。
