Department of Internal Medicine, Boston Medical Center, Boston, MA, USA.
Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
Cancer Causes Control. 2024 Feb;35(2):277-279. doi: 10.1007/s10552-023-01798-5. Epub 2023 Sep 14.
Risk factors for monoclonal gammopathy of undetermined significance (MGUS), the asymptomatic precursor to multiple myeloma, are largely unknown. We hypothesized that low vitamin D levels might be associated with higher MGUS prevalence in a national cohort of U.S. Black women.
We screened archived serum samples (collected 2014-2017) from 3896 randomly selected participants in the Black Women's Health Study ages 50-79 for evidence of MGUS; samples had been assayed for 25-hydroxyvitamin D [25(OH)D] shortly after blood draw. We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for the association between 25(OH)D level and MGUS status, adjusting for age, body mass index, and season of blood draw.
We identified 334 MGUS cases (8.6%) in the study population. The adjusted OR comparing women with vitamin D deficiency (25(OH)D < 20 ng/mL) to those with 25(OH)D levels ≥ 30 ng/mL was 1.27 (95% CI: 0.95, 1.72).
MGUS was more prevalent among Black women with vitamin D deficiency compared to those with 25(OH)D ≥ 30 ng/mL; however, the association was not statistically significant. Future prospective studies are warranted to clarify the possible association between vitamin D and MGUS.
单克隆丙种球蛋白病的不确定意义（MGUS）是多发性骨髓瘤的无症状前体，其危险因素在很大程度上尚不清楚。我们假设，维生素 D 水平低可能与美国黑人女性的国家队列中更高的 MGUS 患病率有关。
我们对 3896 名年龄在 50-79 岁的黑人妇女健康研究中随机选择的参与者的存档血清样本（2014-2017 年采集）进行了 MGUS 检测；在采血后不久，对样本进行了 25-羟维生素 D [25（OH）D] 检测。我们使用逻辑回归来估计 25（OH）D 水平与 MGUS 状态之间的关联的优势比（OR）和 95%置信区间（CI），调整了年龄、体重指数和采血季节。
在研究人群中，我们发现了 334 例 MGUS 病例（8.6%）。与维生素 D 缺乏（25（OH）D < 20ng/mL）的女性相比，25（OH）D 水平≥30ng/mL 的女性的调整 OR 为 1.27（95%CI：0.95，1.72）。
与 25（OH）D≥30ng/mL 的女性相比，维生素 D 缺乏的黑人女性中 MGUS 更为普遍；然而，这种关联没有统计学意义。未来需要前瞻性研究来阐明维生素 D 与 MGUS 之间可能的关联。
