用单克隆抗体检测来自正常结肠黏膜的胰腺癌相关抗原（PCAAc）。

Pancreas cancer associated antigen from normal colonic mucosa (PCAAc) assayed with monoclonal antibody.

作者信息

Kobayashi T, Shimano T, Tatsuta M, Shibata K, Naoi M, Mori T

出版信息

Immunol Lett. 1986 Oct 15;13(5):269-72. doi: 10.1016/0165-2478(86)90112-4.

Abstract

We prepared monoclonal antibodies against pancreatic cancer associated antigen (PCAA) from normal colonic mucosa (PCAAc) and prepared an assay system to detect the circulating PCAAc in sera. 200 patients with cancer including 85 pancreatic cancer and benign disease were compared with 40 normal healthy individuals. Diagnostic rate of pancreatic cancer was 64/85 (75%) but other malignancy also showed elevated PCAAc: 18/19 (94.7%) of hepatoma and 19/37 (51.4%) of gastric cancer. In pancreatitis, 8/17 (47.1%) showed elevated PCAAc. Compared with our previous reports of PCAA assay, these results indicated that diagnostic sensitivity of pancreatic cancer was increased but specificity of it was decreased.

摘要

我们从正常结肠黏膜中制备了针对胰腺癌相关抗原（PCAA）的单克隆抗体（PCAAc），并建立了检测血清中循环PCAAc的检测系统。将包括85例胰腺癌患者和良性疾病患者在内的200例癌症患者与40名正常健康个体进行了比较。胰腺癌的诊断率为64/85（75%），但其他恶性肿瘤患者的PCAAc也升高：肝癌患者中18/19（94.7%），胃癌患者中19/37（51.4%）。在胰腺炎患者中，8/17（47.1%）的PCAAc升高。与我们之前关于PCAA检测的报告相比，这些结果表明胰腺癌的诊断敏感性增加，但特异性降低。