Kitada M, Mori T, Shimano T, Maruyama H, Kosaki G
Clin Chim Acta. 1984 Dec 29;144(2-3):173-83. doi: 10.1016/0009-8981(84)90051-2.
Pancreas cancer-associated antigen (PCAAc) was extracted, isolated and purified from human normal colonic mucosa. Purified PCAAc from normal colonic mucosa was homogeneous, as determined by polyacrylamide disc gel electrophoresis. The PCAAc had a molecular weight of approximately 600 000 and consisted of 30% carbohydrate and 70% protein. It had an isoelectric point of 4.4, and migrated to the alpha 2-beta region on immunoelectrophoresis. It was apparently different from other known gastrointestinal mucus antigens. Antiserum against purified PCAAc did not react with normal human serum, pancreas, liver, spleen or lung, but did react with ascites fluid from a patient with pancreatic cancer. PCAAc appears to be a mucus antigen that is associated with pancreatic cancer.
胰腺癌相关抗原（PCAAc）从人正常结肠黏膜中提取、分离和纯化。通过聚丙烯酰胺圆盘凝胶电泳测定，从正常结肠黏膜中纯化得到的PCAAc是均一的。PCAAc的分子量约为600000，由30%的碳水化合物和70%的蛋白质组成。其等电点为4.4，在免疫电泳中迁移至α2-β区域。它明显不同于其他已知的胃肠道黏液抗原。抗纯化PCAAc的抗血清不与正常人血清、胰腺、肝脏、脾脏或肺发生反应，但与一名胰腺癌患者的腹水发生反应。PCAAc似乎是一种与胰腺癌相关的黏液抗原。
