Cheng Yunzhong, Yang Honghao, Hai Yong, Zhou Lijin
Department of Orthopedic Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Front Mol Biosci. 2022 Aug 11;9:989627. doi: 10.3389/fmolb.2022.989627. eCollection 2022.
Oxidative stress plays a significant role in the development of disc degeneration and has attracted widespread attention since it was first researched in 2007. Our study aims to analyze the scientific output of oxidative stress in intervertebral disc degeneration (IDD) and drive future research into new publications. Publications focused on this topic were retrieved from the SCI-EXPANDED (SCI-E) of the Web of Science (WOS) core collection database and were screened according to the inclusion criteria. Bibliometric website, VOSviewer, and Citespace software were used to evaluate and visualize the results, including annual publications, citations, authors, organizations, countries, research directions, funds, and journals. As of 16 February 2022, a total of 289 original articles and reviews were included, and the overall trend of the number of publications rapidly increased. China and the United States were the leading countries for research production in worldwide. The retrieved 289 publications received 5,979 citations, with an average of 20.67 citations and an H-index of 40. The most high-yield author, organization, country, research direction, fund, and journal were Wang K from Tongji Medical College, Huazhong University of Science Technology, China, Cell Biology, National Natural Science Foundation of China, Oxidative Medicine and Cellular Longevity, respectively. The majority of most common keywords were related to the mechanisms and regulatory networks of oxidative stress. Furthermore, with accumulating evidence that demonstrates the role of oxidative stress in IDD, "mitochondria" and "senescence" are becoming the new research focus that should be paid more attention to.
氧化应激在椎间盘退变的发展过程中起着重要作用，自2007年首次被研究以来就受到了广泛关注。我们的研究旨在分析氧化应激在椎间盘退变（IDD）方面的科研产出，并推动对新发表文献的未来研究。聚焦于该主题的出版物从Web of Science（WOS）核心合集数据库的SCI-EXPANDED（SCI-E）中检索，并根据纳入标准进行筛选。使用文献计量网站、VOSviewer和Citespace软件对结果进行评估和可视化，包括年度出版物、引用情况、作者、机构、国家、研究方向、基金和期刊。截至2022年2月16日，共纳入289篇原创文章和综述，出版物数量的总体趋势迅速增加。中国和美国是全球研究产出的主要国家。检索到的289篇出版物共获得5979次引用，平均每篇引用20.67次，H指数为40。高产作者、机构、国家、研究方向、基金和期刊分别是来自中国华中科技大学同济医学院的王凯、细胞生物学、中国国家自然科学基金、《氧化医学与细胞长寿》。大多数最常见的关键词与氧化应激的机制和调控网络相关。此外，随着越来越多的证据表明氧化应激在IDD中的作用，“线粒体”和“衰老”正成为应更多关注的新研究重点。
