Cheng Yunzhong, Yang Honghao, Hai Yong, Liu Yuzeng
Department of Orthopedic Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
Stem Cells Int. 2022 Sep 1;2022:1274580. doi: 10.1155/2022/1274580. eCollection 2022.
Low back pain (LBP) is a common clinical symptom, and the prevalence is ranged from 60% to 70%. With the deepening of basic research, the development of intervertebral disc regeneration-oriented cell therapy, especially stem and progenitor cells therapy, showed good research prospects and was expected to become new methods of treatment for LBP. Our study is aimed at analyzing the scientific output of stem and progenitor cells in intervertebral discs and at driving future research into new publications. Researches focused on this file were searched from the Science Citation Index Expanded (SCI-E) of the Web of Science (WOS) core collection database and were screened according to inclusion criteria. We evaluated and visualized the results, including annual publications, citations, authors, organizations, countries, research directions, funds, and journals by bibliometric website, VOSviewer, and Citespace softwares on May 27, 2022. A total of 450 original articles and reviews were included, and the overall trend of the number of publications rapidly increased. In worldwide, China and the USA were the leading countries for research production. The retrieved 450 publications received 14322 citations, with an average of 31.83 citations and an H-index of 62. The most high-yield author, organization, country, research directions, funds, and journals were Chen QX from Zhejiang University, Zhejiang University, China, Cell Biology, National Natural Science Foundation of China, and Spine, respectively. Keywords cluster analysis showed the research hotspots in the future, including "human intervertebral disc", "adipose-derived mesenchymal stem cell", "intervertebral disc degeneration", "degenerative disc model", "nucleus pulposus regeneration", "human cartilage", "3d culture", "shrinkage-free preparation", and "polylactide disc". Furthermore, with accumulating evidence demonstrating the role of stem and progenitor cells in intervertebral discs, "microenvironment", "activation", "intervertebral disc degeneration", and "oxidative stress" are becoming the research frontiers and trends.
腰痛（LBP）是一种常见的临床症状，患病率在60%至70%之间。随着基础研究的深入，以椎间盘再生为导向的细胞治疗，尤其是干细胞和祖细胞治疗，展现出良好的研究前景，有望成为腰痛治疗的新方法。我们的研究旨在分析椎间盘干细胞和祖细胞的科研产出，并推动未来新出版物的研究。从Web of Science（WOS）核心合集数据库的科学引文索引扩展版（SCI-E）中检索聚焦于此主题的研究，并根据纳入标准进行筛选。2022年5月27日，我们通过文献计量网站、VOSviewer和Citespace软件对结果进行了评估和可视化，包括年度出版物、引用次数、作者、机构、国家、研究方向、资金和期刊。共纳入450篇原创文章和综述，出版物数量总体呈快速增长趋势。在全球范围内，中国和美国是研究产出的领先国家。检索到的450篇出版物共获得14322次引用，平均每篇引用31.83次，H指数为62。高产作者、机构、国家、研究方向、资金和期刊分别是来自浙江大学的陈QX、浙江大学、中国、细胞生物学、中国国家自然科学基金和《脊柱》杂志。关键词聚类分析显示了未来的研究热点，包括“人类椎间盘”“脂肪来源间充质干细胞”“椎间盘退变”“退变椎间盘模型”“髓核再生”“人类软骨”“三维培养”“无收缩制剂”和“聚乳酸椎间盘”。此外，随着越来越多的证据表明干细胞和祖细胞在椎间盘中的作用，“微环境”“激活”“椎间盘退变”和“氧化应激”正成为研究前沿和趋势。
