克隆于质粒pBR322的乙肝病毒DNA序列在大肠杆菌中的表达。
Expression in Escherichia coli of hepatitis B virus DNA sequences cloned in plasmid pBR322.
作者信息
Burrell C J, Mackay P, Greenaway P J, Hofschneider P H, Murray K
出版信息
Nature. 1979 May 3;279(5708):43-7. doi: 10.1038/279043a0.
DOI:10.1038/279043a0
PMID:377093
Abstract
Fragments of hepatitis B virus DNA isolated from Dane particles have been inserted into the Escherichia coli plasmid pBR322 and cloned. Cells carrying the hybrid plasmid synthesise antigenic material that reacts specifically with antisera to hepatitis B viral antigens.
摘要
从 Dane 颗粒中分离出的乙肝病毒 DNA 片段已被插入大肠杆菌质粒 pBR322 并进行克隆。携带杂交质粒的细胞合成与乙肝病毒抗原抗血清发生特异性反应的抗原物质。
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