Bekele Adamu T
Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, P.O. Box 9086, Addis Ababa, Ethiopia.
Curr Heart Fail Rep. 2023 Oct;20(5):429-440. doi: 10.1007/s11897-023-00628-8. Epub 2023 Sep 15.
Heart failure is defined as a complex clinical syndrome that results from any structural or functional impairment of ventricular filling or ejection of blood. The natriuretic peptide is known to exert its biological action on the kidney, heart, blood vessels, renin-angiotensin system, autonomous nervous system, and central nervous system. The natriuretic peptide-natriuretic receptor system plays an important role in the regulation of blood pressure and body fluid volume through its pleiotropic effects.
The clinical and animal studies suggest that natriuretic peptide-natriuretic receptors are important targets for the treatment of heart failure and other cardiovascular diseases. Even though attempts targeting natriuretic peptide receptors are underway for heart failure treatment, they seem insufficient despite the receptor systems' potential. This review summarizes natriuretic peptide-natriuretic receptor system's physiological actions and potential target for the treatment of heart failure. Natriuretic peptides play multiple roles in different parts of the body, almost all of the activities related to this receptor system appear to have the potential to be harnessed to treat heart failure or symptoms associated with heart failure.
心力衰竭被定义为一种复杂的临床综合征，由心室充盈或射血的任何结构或功能损害引起。已知利钠肽对肾脏、心脏、血管、肾素-血管紧张素系统、自主神经系统和中枢神经系统发挥其生物学作用。利钠肽-利钠肽受体系统通过其多效性作用在血压和体液量的调节中起重要作用。
临床和动物研究表明，利钠肽-利钠肽受体是治疗心力衰竭和其他心血管疾病的重要靶点。尽管针对利钠肽受体治疗心力衰竭的尝试正在进行中，但尽管受体系统具有潜力，这些尝试似乎并不充分。本综述总结了利钠肽-利钠肽受体系统的生理作用以及治疗心力衰竭的潜在靶点。利钠肽在身体不同部位发挥多种作用，几乎所有与该受体系统相关的活动似乎都有潜力用于治疗心力衰竭或与心力衰竭相关的症状。
