甘油三酯与合并非酒精性脂肪肝的急性胰腺炎严重程度的关系：一项回顾性研究。
Relation between triglycerides and the severity of acute pancreatitis combined with nonalcoholic fatty liver disease: a retrospective study.
机构信息
Department of Gastroenterology, Northern Jiangsu People's Hospital, Yangzhou University, No 98, Nantong West Rd, Yangzhou, Jiangsu, China, 225000.
出版信息
BMC Gastroenterol. 2023 Sep 14;23(1):313. doi: 10.1186/s12876-023-02951-9.
BACKGROUND
Nonalcoholic fatty liver disease (NAFLD) can exacerbate the severity of acute pancreatitis (AP), and this severity is worsened with increased severity of NAFLD. This study aimed to investigate the relation between serum triglyceride (TG) and the severity of AP with NAFLD by collecting clinical data from AP patients with NAFLD.
METHODS
AP patients with NAFLD were divided into 2 groups according to TG levels: hypertriglyceridemia (HTG) group and non-hypertriglyceridemia (NHTG) group.
RESULTS
In total, 598 AP patients with NAFLD were enrolled in this study, including 433 in the HTG group and 165 in the NHTG group. Compared with the NHTG group, AP patients in the HTG group were more serious (P < 0.05). The incidence of persistent organ failure (POF), especially persistent respiratory failure, and the ratio of acute peripancreatic fluid collection (APFC) were higher in the HTG group (P < 0.05). Higher TG levels were associated with a higher incidence of APFC (P < 0.05). Logistic regression analysis showed that the risk of APFC was significantly higher in moderate and severe NAFLD than in mild NAFLD.
CONCLUSION
HTG may aggravate the severity and local complications of AP combined with NAFLD.
背景
非酒精性脂肪性肝病（NAFLD）可使急性胰腺炎（AP）的严重程度恶化，且随着 NAFLD 严重程度的增加，其严重程度会进一步加重。本研究旨在通过收集合并 NAFLD 的 AP 患者的临床资料，研究血清甘油三酯（TG）与合并 NAFLD 的 AP 严重程度之间的关系。
方法
根据 TG 水平将合并 NAFLD 的 AP 患者分为两组：高甘油三酯血症（HTG）组和非高甘油三酯血症（NHTG）组。
结果
本研究共纳入 598 例合并 NAFLD 的 AP 患者，其中 HTG 组 433 例，NHTG 组 165 例。与 NHTG 组相比，HTG 组的 AP 患者病情更严重（P<0.05）。HTG 组持续性器官衰竭（POF）的发生率，尤其是持续性呼吸衰竭的发生率较高，急性胰周液体积聚（APFC）的比例也较高（P<0.05）。TG 水平越高，APFC 的发生率越高（P<0.05）。Logistic 回归分析显示，中重度 NAFLD 发生 APFC 的风险显著高于轻度 NAFLD。
结论
HTG 可能加重合并 NAFLD 的 AP 的严重程度和局部并发症。
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