牙周炎与乌干达糖尿病成人患者的胰岛素抵抗有关：一项横断面研究。
Periodontitis is associated with insulin resistance in adults living with diabetes mellitus in Uganda: a cross- sectional study.
机构信息
Department of Anatomy, Makerere University College of Health Sciences, P.O. Box 7072, Kampala, Uganda.
School of Dentistry, Makerere University College of Health Sciences, P.O. Box 7072, Kampala, Uganda.
出版信息
BMC Res Notes. 2023 Sep 14;16(1):217. doi: 10.1186/s13104-023-06473-1.
INTRODUCTION
Evidence suggests that majority of patients with diabetes mellitus in Uganda have poor glycaemic control as well as periodontal disease. This study set out to determine the association between periodontitis and insulin resistance in adult patients with diabetes mellitus in Uganda using the triglyceride glucose index.
METHODS
Two hundred and twenty-three adult study participants with confirmed diabetes mellitus were enrolled in a cross-sectional study. Oral examination was carried with the aid of a periodontal probe to determine the periodontal status and findings recorded using the WHO Oral Health Assessment Tool for Adults, 2013. We recorded clinical details for body mass index (BMI in kg/m) and laboratory parameters including fasting blood sugar (mmol/L), glycated hemoglobin levels (HbA1c, %) and serum triglycerides (mmol/L) using a study questionnaire. Data were analyzed using R version 4.10. The glucose triglyceride index was used as a measure of insulin resistance. Logistic regression analysis carried out to determine the factors associated insulin resistance.
RESULTS
The majority of the study participants was female (70%) with an average age of 48.5 years (SD+/- 11.1). The mean body mass index was 29.6 kg/m (SD+/- 5.82). The mean serum triglyceride index was 9.48 (SD+/- 0.675). Eighty-six-point 1% of the participants had periodontal disease. Bivariate analysis revealed high odds for male sex (OR = 1.31, 95% C.I = 0.44-4.84, p = 0.65) and periodontitis (OR = 3.65, 95% C.I = 0.79-26.15, p = 0.13) but low odds for a high BMI (OR = 0.45. 95% C.I = 0.07-1.67, p = 0.30). Multivariate regression revealed a significant association between insulin resistance and periodontitis. (AOR = 3.52, 95% C.I = 1.19-1.83, p = 0.03).
CONCLUSION
Insulin resistance is highly prevalent in patients with diabetes mellitus in Uganda and is associated with periodontitis and low body weight.
简介
有证据表明，乌干达多数糖尿病患者的血糖控制和牙周病都很差。本研究旨在使用甘油三酯葡萄糖指数，确定乌干达成年糖尿病患者牙周炎与胰岛素抵抗之间的关系。
方法
对 223 名确诊的糖尿病成年患者进行横断面研究。借助牙周探针进行口腔检查，以确定牙周状况，并使用 2013 年世界卫生组织成人口腔健康评估工具记录检查结果。我们使用研究问卷记录了体重指数（BMI，kg/m）和实验室参数，包括空腹血糖（mmol/L）、糖化血红蛋白水平（HbA1c，%）和血清甘油三酯（mmol/L）。数据使用 R 版本 4.10 进行分析。甘油三酯葡萄糖指数被用作衡量胰岛素抵抗的指标。采用逻辑回归分析确定与胰岛素抵抗相关的因素。
结果
大多数研究参与者为女性（70%），平均年龄为 48.5 岁（SD+/-11.1）。平均体重指数为 29.6 kg/m（SD+/-5.82）。平均血清甘油三酯指数为 9.48（SD+/-0.675）。86.1%的参与者患有牙周病。双变量分析显示，男性（OR=1.31，95%CI=0.44-4.84，p=0.65）和牙周炎（OR=3.65，95%CI=0.79-26.15，p=0.13）的患病风险较高，但体重指数较高（OR=0.45，95%CI=0.07-1.67，p=0.30）的患病风险较低。多变量回归显示，胰岛素抵抗与牙周炎之间存在显著关联（AOR=3.52，95%CI=1.19-1.83，p=0.03）。
结论
乌干达的糖尿病患者胰岛素抵抗很常见，且与牙周炎和低体重有关。
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