Special Key Laboratory of Oral Diseases Research, Hospital/School of Stomatology, Zunyi Medical University, Zunyi 563099, Guizhou, China.
Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi 563099, Guizhou, China.
Biomed Environ Sci. 2023 Aug 20;36(8):743-755. doi: 10.3967/bes2023.079.
This review aims to sum up how Non-coding RNAs (ncRNAs) regulate the development of periodontitis and provides a new perspective for understanding the pathogenesis of periodontitis. We explored the ncRNA's dual role in the development of periodontitis by summarizing evidence from previous and studies as well as clinical samples. In our review, the downregulation of 18 miRNAs, 22 lncRNAs and 10 circRNAs demonstrates protective roles in periodontitis. In contrast, the expression of other 11 miRNAs, 7 lncRNAs and 6 circRNAs are upregulated in periodontitis, which promote the progression of periodontitis. These dysregulated ncRNAs exert their protective or destructive roles by mainly influencing cell proliferation, differentiation and apoptosis cross-talking with various molecules or signaling pathways. Our findings suggested which and how ncRNAs promote or delay the progression of periodontitis, which may greatly contribute to diagnose and therapy development of periodontitis based on ncRNAs in the future.
本篇综述旨在总结非编码 RNA（ncRNA）如何调控牙周炎的发生发展，并为理解牙周炎的发病机制提供新视角。通过总结既往研究和临床样本的证据，我们探讨了 ncRNA 在牙周炎发生发展过程中的双重作用。在本综述中，下调的 18 个 miRNA、22 个 lncRNA 和 10 个 circRNA 显示出对牙周炎的保护作用。相比之下，牙周炎中上调的其他 11 个 miRNA、7 个 lncRNA 和 6 个 circRNA 促进了牙周炎的进展。这些失调的 ncRNA 主要通过影响细胞增殖、分化和凋亡来发挥其保护或破坏作用，并与各种分子或信号通路发生相互作用。我们的研究结果表明，ncRNA 以何种方式促进或延缓牙周炎的进展，这可能有助于未来基于 ncRNA 诊断和治疗牙周炎。
