State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
J Periodontal Res. 2021 Oct;56(5):848-862. doi: 10.1111/jre.12910. Epub 2021 Jul 23.
Periodontitis is a major burden of public health, affecting 20%-50% of the global population. It is a complex inflammatory disease characterized by the destruction of supporting structures of the teeth, leading to tooth loss and the emergence or worsening of systematic diseases. Understanding the molecular mechanisms underlying the physiopathology of periodontitis is beneficial for targeted therapeutics. Long non-coding RNAs (lncRNAs), transcripts made up of more than 200 nucleotides, have emerged as novel regulators of many biological and pathological processes. Recently, an increasing number of dysregulated lncRNAs have been found to be implicated in periodontitis. In this review, an overview of lncRNAs, including their biogenesis, characteristics, function mechanisms and research approaches, is provided. And we summarize recent research reports on the emerging roles of lncRNAs in regulating proliferation, apoptosis, inflammatory responses, and osteogenesis of periodontal cells to elucidate lncRNAs related physiopathology of periodontitis. Furthermore, we have highlighted the underlying mechanisms of lncRNAs in periodontitis pathology by interacting with microRNAs. Finally, the potential clinical applications, current challenges, and prospects of lncRNAs as diagnostic and prognostic biomarkers and therapeutic targets for periodontitis disease are discussed.
牙周炎是一种主要的公共卫生负担，影响全球 20%-50%的人口。它是一种复杂的炎症性疾病，其特征是牙齿支持结构的破坏，导致牙齿脱落和系统性疾病的出现或恶化。了解牙周炎病理生理学的分子机制有助于靶向治疗。长链非编码 RNA（lncRNA）是由超过 200 个核苷酸组成的转录本，它们已成为许多生物学和病理学过程的新型调节因子。最近，越来越多的失调 lncRNA 被发现与牙周炎有关。在这篇综述中，概述了 lncRNA，包括它们的生物发生、特征、功能机制和研究方法。并总结了 lncRNA 调节牙周细胞增殖、凋亡、炎症反应和骨生成的新兴作用的最新研究报告，以阐明 lncRNA 与牙周炎相关的病理生理学。此外，通过与 microRNA 相互作用，强调了 lncRNA 在牙周炎病理学中的潜在机制。最后，讨论了 lncRNA 作为牙周炎疾病的诊断和预后生物标志物和治疗靶点的潜在临床应用、当前挑战和前景。
