Carpino F, Di Tondo U, Picardi N, Gaudio E, Paggiarino D, Santeusanio G, Bosco S, Melis M
Ital J Surg Sci. 1986;16(2):127-32.
The effects of central and peripheral duct occlusion on the pancreas of the pig were investigated. The occlusion was obtained by injecting into the distal part of the pancreatic duct an ether diluted delicron or a fluid silicone solution. The pancreatic duct was then interrupted. At different intervals, gross morphology of the residual pancreas was studied and specimens were obtained for histology, immunocytochemistry and electronmicroscopy. A rapid progression of sclerotic modifications, with gradual destruction of exocrine gland, substantially concluded after 60 days, was demonstrated. However Langerhans' islets appeared preserved. These findings permit to suggest the application of this valid experimental model of chronic pancreatitis to the conservative treatment of human chronic pancreatitis.
研究了猪胰腺中央和外周导管阻塞的影响。通过向胰管远端注射稀释的乙醚或液态硅胶溶液来实现阻塞。然后中断胰管。在不同时间间隔，研究残余胰腺的大体形态，并获取标本进行组织学、免疫细胞化学和电子显微镜检查。结果表明，硬化性改变迅速进展，外分泌腺逐渐破坏，60天后基本结束。然而，胰岛似乎保持完好。这些发现提示可将这种有效的慢性胰腺炎实验模型应用于人类慢性胰腺炎的保守治疗。
