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本文引用的文献

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Treatment-resistant depression: definition, prevalence, detection, management, and investigational interventions.难治性抑郁症：定义、患病率、检测、管理及研究性干预措施。
World Psychiatry. 2023 Oct;22(3):394-412. doi: 10.1002/wps.21120.
2
Adjunctive Cariprazine for the Treatment of Patients With Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study.阿立哌唑辅助治疗重度抑郁症患者：一项随机、双盲、安慰剂对照的3期研究。
Am J Psychiatry. 2023 Mar 1;180(3):241-251. doi: 10.1176/appi.ajp.20220504. Epub 2023 Feb 15.
3
What to Expect When Switching to a Second Antidepressant Medication Following an Ineffective Initial SSRI: A Report From the Randomized Clinical STAR*D Study.在初始 SSRI 治疗无效后改用第二种抗抑郁药时的预期：来自随机临床试验 STAR*D 的报告。
J Clin Psychiatry. 2020 Aug 11;81(5):19m12949. doi: 10.4088/JCP.19m12949.
4
Efficacy and Safety of Flexibly Dosed Esketamine Nasal Spray Combined With a Newly Initiated Oral Antidepressant in Treatment-Resistant Depression: A Randomized Double-Blind Active-Controlled Study.灵活剂量依他佐辛鼻喷雾剂联合新起始口服抗抑郁药治疗难治性抑郁症的疗效和安全性：一项随机、双盲、活性对照研究。
Am J Psychiatry. 2019 Jun 1;176(6):428-438. doi: 10.1176/appi.ajp.2019.19020172. Epub 2019 May 21.
5
The assessment of resistance to antidepressant treatment: Rationale for the Antidepressant Treatment History Form: Short Form (ATHF-SF).抗抑郁治疗抵抗的评估：抗抑郁治疗史表单：简短版（ATHF-SF）的原理。
J Psychiatr Res. 2019 Jun;113:125-136. doi: 10.1016/j.jpsychires.2019.03.021. Epub 2019 Mar 22.
6
A multidimensional tool to quantify treatment resistance in depression: the Maudsley staging method.一种量化抑郁症治疗抵抗性的多维工具：莫兹利分期法。
J Clin Psychiatry. 2009 Feb;70(2):177-84. doi: 10.4088/jcp.08m04309. Epub 2009 Jan 27.
7
Meta-analysis of major depressive disorder relapse and recurrence with second-generation antidepressants.第二代抗抑郁药治疗重度抑郁症复发和再发的荟萃分析。
Psychiatr Serv. 2008 Oct;59(10):1121-30. doi: 10.1176/ps.2008.59.10.1121.
8
Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report.需要一个或多个治疗步骤的抑郁症门诊患者的急性和长期转归：STAR*D报告
Am J Psychiatry. 2006 Nov;163(11):1905-17. doi: 10.1176/ajp.2006.163.11.1905.
9
Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice.在STAR*D研究中采用基于测量的护理评估西酞普兰治疗抑郁症的疗效：对临床实践的启示
Am J Psychiatry. 2006 Jan;163(1):28-40. doi: 10.1176/appi.ajp.163.1.28.

Challenges of research on treatment-resistant depression: a clinician's perspective.

作者信息

Rush A John

机构信息

Duke-National University of Singapore, Singapore; Duke Medical School, Durham, NC, USA.

出版信息

World Psychiatry. 2023 Oct;22(3):415-417. doi: 10.1002/wps.21136.

DOI:10.1002/wps.21136
PMID:37713554
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10503908/
Abstract
摘要