Department of Radiology, Shanghai Pudong New Area People's Hospital, Shanghai, China.
Department of Neurology, Shanghai Pudong New Area People's Hospital, Shanghai, China.
Medicine (Baltimore). 2023 Sep 15;102(37):e34979. doi: 10.1097/MD.0000000000034979.
We aimed to investigate the role of combined apparent diffusion coefficient (ADC) values and relative cerebral blood flow (rCBF) values in the diagnosis of mild cognitive impairment (MCI) patients. The present prospective research enrolled 156 MCI patients and 58 healthy elderly people who came to our hospital from January 2021 to February 2023. T1W, T2W, diffusion-weighted imaging, and arterial spin labeling sequences were performed on all subjects, and ADC values and rCBF values were measured at the workstation. Clinical and demographic data of all patients were collected while mini-mental state examination (MMSE) and Montreal cognitive assessment (MoCA) scores were used to assess patients' cognitive abilities. The MCI group had significantly lower rCBF values in the left frontal lobe, left occipital lobe, right frontal lobe, and right occipital lobe than the HC group. The ADC values in the left frontal lobe as well as the right frontal lobe were remarkably elevated in the MCI group than in the HC group. MoCA and MMSE scores were positively correlated with rCBF values in the left frontal, right frontal, left occipital, and right occipital lobes and negatively correlated with ADC values in the left and right frontal lobes. Combined ADC values and rCBF values from the left frontal lobe for the diagnosis of MCI had a higher sensitivity and specificity with the AUC was 0.877, sensitivity 81.0%, specificity 82.7%. Additionally, pressure fasting plasma glucose, ADC of the left frontal lobe, right frontal lobe, rCBF of left frontal lobe and rCBF of left frontal lobe were the risk factors of patients with MCI. In summary, our results indicated that the ADC values and rCBF values were changed in MCI group compared to HC group and correlated with MMSE and MoCA scores.
我们旨在探讨联合表观扩散系数（ADC）值和相对脑血流量（rCBF）值在轻度认知障碍（MCI）患者诊断中的作用。本前瞻性研究纳入了 2021 年 1 月至 2023 年 2 月期间来我院的 156 名 MCI 患者和 58 名健康老年人。所有受试者均行 T1W、T2W、弥散加权成像和动脉自旋标记序列检查，并在工作站测量 ADC 值和 rCBF 值。收集所有患者的临床和人口统计学数据，同时使用简易精神状态检查（MMSE）和蒙特利尔认知评估（MoCA）评分评估患者的认知能力。MCI 组左侧额叶、左侧枕叶、右侧额叶和右侧枕叶的 rCBF 值明显低于 HC 组。MCI 组左侧额叶和右侧额叶的 ADC 值明显高于 HC 组。MoCA 和 MMSE 评分与左侧额叶、右侧额叶、左侧枕叶和右侧枕叶的 rCBF 值呈正相关，与左侧和右侧额叶的 ADC 值呈负相关。左侧额叶 ADC 值和 rCBF 值联合诊断 MCI 的敏感性和特异性较高，AUC 为 0.877，敏感性为 81.0%，特异性为 82.7%。此外，空腹血糖、左侧额叶 ADC 值、右侧额叶 ADC 值、左侧额叶 rCBF 值和左侧额叶 rCBF 值是 MCI 患者的危险因素。总之，我们的研究结果表明，与 HC 组相比，MCI 组的 ADC 值和 rCBF 值发生了变化，并且与 MMSE 和 MoCA 评分相关。
