Izak-Nau Emilia, Niggemann Louisa P, Göstl Robert
DWI-Leibniz Institute for Interactive Materials, Forckenbeckstr. 50, 52056, Aachen, Germany.
Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, Worringerweg 2, 52074, Aachen, Germany.
Small. 2024 Jan;20(4):e2304527. doi: 10.1002/smll.202304527. Epub 2023 Sep 15.
Magnetic nanoparticles (NPs) are widely employed for remote controlled molecular release applications using alternating magnetic fields (AMF). Yet, they intrinsically generate heat in the process by Néel relaxation limiting their application scope. In contrast, iron oxide NPs larger than ≈15 nm react to AMF by Brownian relaxation resulting in tumbling and shaking. Here, such iron oxide NPs are combined with polymer shells where the shaking motion mechanically agitates and partially detaches the polymer chains, covalently cleaves a fraction of the polymers, and releases the prototypical cargo molecules doxorubicin and curcumin into solution. This heat-free release mechanism broadens the potential application space of polymer-functionalized magnetic NP composites.
磁性纳米颗粒（NPs）被广泛应用于利用交变磁场（AMF）进行远程控制的分子释放应用中。然而，它们在这个过程中会通过奈尔弛豫本质上产生热量，从而限制了它们的应用范围。相比之下，大于约15纳米的氧化铁纳米颗粒通过布朗弛豫对交变磁场做出反应，导致翻滚和摇晃。在这里，这种氧化铁纳米颗粒与聚合物壳相结合，摇晃运动会机械地搅动并部分分离聚合物链，共价裂解一部分聚合物，并将典型的载药分子阿霉素和姜黄素释放到溶液中。这种无热释放机制拓宽了聚合物功能化磁性纳米颗粒复合材料的潜在应用空间。
