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交变磁场中铁氧化物纳米笼的磁诱导布朗运动及其在高效 siRNA 递送中的应用。

Magnetically Induced Brownian Motion of Iron Oxide Nanocages in Alternating Magnetic Fields and Their Application for Efficient siRNA Delivery.

机构信息

Department of Chemistry, Hunter College, City University of New York, 695 Park Avenue, New York, New York10065, United States.

Ph.D. Program in Biochemistry, The Graduate Center of the City University of New York, New York, New York10016, United States.

出版信息

Nano Lett. 2022 Nov 23;22(22):8852-8859. doi: 10.1021/acs.nanolett.2c02691. Epub 2022 Nov 8.

DOI:10.1021/acs.nanolett.2c02691
PMID:36346801
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9879328/
Abstract

Hyperthermia of superparamagnetic nanoparticles driven by Néel relaxation in an alternating magnetic field (AMF) has been studied in biomedical areas; however, Brownian motion, induced by another magnetic relaxation mechanism, has not been explored extensively despite its potential in intracellular mechanoresponsive applications. We investigated whether superparamagnetic cage-shaped iron oxide nanoparticles (IO-nanocages), previously demonstrated to carry payloads inside their cavities for drug delivery, can generate Brownian motion by tuning the nanoparticle size at 335 kHz AMF frequency. The motivation of this work is to examine the magnetically driven Brownian motion for the delivery of nanoparticles allowing escape from endosomes before digestion in lysosomes and efficient delivery of siRNA cargoes to the cytoplasm. Superconducting quantum interference device (SQUID) measurements reveal the nanocage size dependence of Brownian relaxation, and a magnetic Brownian motion of 20 nm IO-nanocages improved the efficiency of siRNA delivery while endosomal membranes were observed to be compromised to release IO-nanocages in AMFs during the delivery process.

摘要

超顺磁纳米颗粒的尼耳弛豫在交变磁场（AMF）中的过热现象已在生物医学领域得到研究；然而，尽管另一种磁弛豫机制诱导的布朗运动在细胞内机械响应应用中有很大的潜力，但尚未得到广泛的探索。我们研究了笼型超顺磁氧化铁纳米颗粒（IO-纳米笼）是否可以通过在 335 kHz AMF 频率下调整纳米颗粒尺寸来产生布朗运动，此前已经证明这些纳米颗粒可以在其空腔内携带有效载荷进行药物输送。这项工作的动机是研究磁驱动布朗运动在纳米颗粒输送中的应用，以便在溶酶体消化之前从内涵体中逃逸，并有效地将 siRNA 货物递送到细胞质中。超导量子干涉装置（SQUID）测量揭示了布朗弛豫与纳米笼尺寸的依赖性，并且 20nm IO-纳米笼的磁布朗运动提高了 siRNA 传递的效率，同时在传递过程中观察到内涵体膜在 AMF 中受损，以释放 IO-纳米笼。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22de/9879328/fc54c6e9427c/nihms-1863128-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22de/9879328/3003dd813174/nihms-1863128-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22de/9879328/408550879bdd/nihms-1863128-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22de/9879328/8b79ac25d646/nihms-1863128-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22de/9879328/4da62e895da7/nihms-1863128-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22de/9879328/fc54c6e9427c/nihms-1863128-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22de/9879328/3003dd813174/nihms-1863128-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22de/9879328/408550879bdd/nihms-1863128-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22de/9879328/8b79ac25d646/nihms-1863128-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22de/9879328/4da62e895da7/nihms-1863128-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22de/9879328/fc54c6e9427c/nihms-1863128-f0005.jpg

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