Ain Shams University, Cairo, Egypt.
The Ministry of Health and Population, Cairo, Egypt.
J Atten Disord. 2024 Jan;28(1):66-76. doi: 10.1177/10870547231197213. Epub 2023 Sep 16.
ADHD has a multi-factorial etiology among which the inflammatory theory presupposition. We aimed to explore the interplay between blood inflammatory markers; neutrophil lymphocyte ratios (NLR), platelet\lymphocyte ratio (PLR), mean platelet volume (MPV), symptom domains, and severity of ADHD.
A total of 50 children with ADHD and 50 healthy controls were recruited. Children were assessed using the mini-international neuropsychiatric interview for children and adolescents (MINI-KID), the Wechsler intelligence scale for children, the Conners' parent rating scale. Then, NLR, PLR, and MPV were measured.
There was a statistically significant difference between children with ADHD and the control group with regard to all blood inflammatory markers (except platelet count). The subtypes and severity of ADHD had no significant relation with NLR, PLR, and MPV.
blood inflammatory markers are significantly high in children with ADHD but could not predict specific symptom domains or severity.
ADHD 的病因具有多因素性，其中炎症理论假设。我们旨在探讨血液炎症标志物；中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、平均血小板体积（MPV）、症状领域和 ADHD 严重程度之间的相互作用。
共招募了 50 名 ADHD 儿童和 50 名健康对照者。使用儿童迷你国际神经精神访谈（MINI-KID）、儿童韦氏智力量表和康纳斯父母评定量表对儿童进行评估。然后，测量 NLR、PLR 和 MPV。
ADHD 儿童与对照组在所有血液炎症标志物（血小板计数除外）方面存在统计学显著差异。ADHD 的亚型和严重程度与 NLR、PLR 和 MPV 无显著关系。
ADHD 儿童的血液炎症标志物显著升高，但不能预测特定的症状领域或严重程度。
