Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China; Laboratory of Data Discovery for Health (D(2)4H), Hong Kong Science and Technology Park, Hong Kong Special Administrative Region, China; Department of Family Medicine and Primary Care, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Department of Family Medicine and Primary Care, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Cell Rep Med. 2023 Oct 17;4(10):101195. doi: 10.1016/j.xcrm.2023.101195. Epub 2023 Sep 15.
It is unknown if vaccination affects the risk of post-COVID-19 cardiovascular diseases (CVDs). Therefore, this retrospective cohort study examines the short-term and long-term risks of post-infection CVD among COVID-19 patients with different vaccination status utilizing data from electronic health databases in Hong Kong. Cox proportional hazards regression adjusted with inverse probability of treatment weighting is used to evaluate the risks of incident CVD (coronary heart disease, stroke, heart failure) and all-cause mortality in COVID-19 patients. Compared with unvaccinated patients, vaccinated patients have a lower risk of CVD and all-cause mortality, and the lowest risk is observed in those who completed three doses of vaccine. Similar patterns in the subgroups of different vaccine platforms, age, gender, Charlson comorbidity index, and disease severity are observed. These findings highlight a positive dose-response relationship between overall CVD risk reduction and the number of vaccine doses received.
目前尚不清楚疫苗接种是否会影响 COVID-19 后心血管疾病（CVD）的风险。因此，本回顾性队列研究利用香港电子健康数据库中的数据，检查了不同疫苗接种状态的 COVID-19 患者感染后 CVD 的短期和长期风险。使用逆概率治疗加权的 Cox 比例风险回归来评估 COVID-19 患者新发 CVD（冠心病、中风、心力衰竭）和全因死亡率的风险。与未接种疫苗的患者相比，接种疫苗的患者 CVD 和全因死亡率的风险较低，而接种三剂疫苗的患者风险最低。在不同疫苗平台、年龄、性别、Charlson 合并症指数和疾病严重程度的亚组中观察到类似的模式。这些发现强调了 CVD 总体风险降低与接种疫苗剂量之间的正剂量反应关系。
