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空中医疗输血作为大量输血方案的触发因素。

Air Medical Blood Transfusion as a Trigger of Massive Transfusion Protocol.

机构信息

Graduate Program in Nurse Anesthesia, Texas Wesleyan University, Fort Worth, TX; Department of Anesthesia, John Peter Smith Hospital, Fort Worth, TX; Department of Anesthesia, Ochsner LSU Health, Shreveport, LA.

Department of Emergency Medicine, Louisiana State University Health Sciences Center, Shreveport, LA.

出版信息

Air Med J. 2023 Sep-Oct;42(5):353-357. doi: 10.1016/j.amj.2023.05.007. Epub 2023 Jun 26.

DOI:10.1016/j.amj.2023.05.007
PMID:37716807
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10540275/
Abstract

Air medical services can improve access to blood products at the point of injury. Studies have shown that early activation of mass transfusion protocols (MTPs) can improve the survival of trauma patients by up to 25%. There are several scoring systems to guide early activation, but the use of a single criterion has been elusive. Our study sought to determine if air medical administration of blood products was a risk factor for massive transfusion activation and utilization of prehospital vital signs for calculation of the shock index. In our retrospective study, we evaluated adult trauma patients transfused by helicopter emergency medical services (HEMS) and as a control all patients in our institution receiving the MTP. Our study found HEMS blood transfusion was not a reliable trigger for MTP, although the sample size may have limited our findings. We found that HEMS care resulted in an overall reduction in the volume of transfusion and an improvement in hemodynamic parameters upon trauma center arrival. HEMS transfusion and a higher rate of tranexamic acid administration may have contributed to these findings. Of note, the assessment of blood consumption score and shock index were nonspecific in the study populations.

摘要

空中医疗服务可以改善受伤时的血液制品获取。研究表明,早期启动大量输血方案 (MTP) 可以将创伤患者的生存率提高多达 25%。有几种评分系统可以指导早期激活,但单一标准的使用一直难以实现。我们的研究旨在确定空中医疗用血是否是大量输血激活的危险因素,以及是否利用院前生命体征计算休克指数。在我们的回顾性研究中,我们评估了接受直升机紧急医疗服务 (HEMS) 输血的成年创伤患者,并将我们机构中接受 MTP 的所有患者作为对照。我们的研究发现,HEMS 输血并不是 MTP 的可靠触发因素,尽管样本量可能限制了我们的发现。我们发现,HEMS 护理导致创伤中心到达时的输血总量减少和血流动力学参数改善。HEMS 输血和更高的氨甲环酸使用率可能促成了这些发现。值得注意的是,研究人群中血液消耗评分和休克指数的评估不具有特异性。

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本文引用的文献

1
Platelet Transfusion and Outcomes After Massive Transfusion Protocol Activation for Major Trauma: A Retrospective Cohort Study.血小板输注与大创伤大量输血方案激活后的结局:一项回顾性队列研究。
Anesth Analg. 2022 Aug 1;135(2):385-393. doi: 10.1213/ANE.0000000000005982. Epub 2022 May 6.
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Blood product transfusion during air medical transport: A needs assessment.空中医疗转运期间的血液制品输注:需求评估。
CJEM. 2020 Sep;22(S2):S67-S73. doi: 10.1017/cem.2020.2.
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Association of Prehospital Plasma Transfusion With Survival in Trauma Patients With Hemorrhagic Shock When Transport Times Are Longer Than 20 Minutes: A Post Hoc Analysis of the PAMPer and COMBAT Clinical Trials.
创伤伴出血性休克患者院前输注血浆与生存的相关性:当转运时间超过 20 分钟时——对 PAMPer 和 COMBAT 临床试验的事后分析。
JAMA Surg. 2020 Feb 1;155(2):e195085. doi: 10.1001/jamasurg.2019.5085. Epub 2020 Feb 19.
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Review of massive transfusion protocols in the injured, bleeding patient.创伤及出血患者大量输血方案的综述。
Curr Opin Crit Care. 2019 Dec;25(6):661-667. doi: 10.1097/MCC.0000000000000668.
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A Retrospective Study of Transfusion Requirements in Trauma Patients Receiving Tranexamic Acid.接受氨甲环酸的创伤患者输血需求的回顾性研究
J Trauma Nurs. 2019 May/Jun;26(3):128-133. doi: 10.1097/JTN.0000000000000437.
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Systematic reviews of scores and predictors to trigger activation of massive transfusion protocols.用于触发大量输血方案激活的评分和预测因子的系统评价。
J Trauma Acute Care Surg. 2019 Sep;87(3):717-729. doi: 10.1097/TA.0000000000002372.
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Massive transfusion triggers in severe trauma: Scoping review.严重创伤中的大量输血触发因素:范围综述
Rev Lat Am Enfermagem. 2018 Nov 29;26:e3102. doi: 10.1590/1518-8345.2574.3102.
8
Pre-hospital transfusion of red blood cells in civilian trauma patients.civilian创伤患者院前输注红细胞
Transfus Med. 2018 Aug;28(4):277-283. doi: 10.1111/tme.12483. Epub 2017 Oct 24.
9
Association of Prehospital Blood Product Transfusion During Medical Evacuation of Combat Casualties in Afghanistan With Acute and 30-Day Survival.阿富汗战斗伤员医疗后送期间院前血液制品输注与急性生存及30天生存率的关联
JAMA. 2017 Oct 24;318(16):1581-1591. doi: 10.1001/jama.2017.15097.
10
Accuracy of shock index versus ABC score to predict need for massive transfusion in trauma patients.休克指数与ABC评分预测创伤患者大量输血需求的准确性。
Injury. 2018 Jan;49(1):15-19. doi: 10.1016/j.injury.2017.09.015. Epub 2017 Sep 15.