Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Key Laboratory of Chinese Medicinal Resources Recycling Utilization of National Administration of Traditional Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China; Department of Pharmacy, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China.
Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Key Laboratory of Chinese Medicinal Resources Recycling Utilization of National Administration of Traditional Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Int J Biol Macromol. 2023 Dec 31;253(Pt 3):126930. doi: 10.1016/j.ijbiomac.2023.126930. Epub 2023 Sep 17.
Carboxymethyl chitosan and resistant starch exhibit good performance in diabetes regulation. We prepared carboxymethyl chitosan - resistant starch complex. Test the properties of composite resistant starch by using X-ray diffraction, water contact angle, infrared spectroscopy, and scanning electron microscopy, interactions with intestinal microbiota and mouse experiments were also conducted. The results indicated that the composite resistant starch had a good effect on promoting the proliferation of probiotics on Bifidobacterium and a significant inhibitory effect on Escherichia coli than resistant starch (P < 0.05). After administration, the water intake and weight of diabetic mice were significantly reduced. The blood glucose of diabetic mice was also reduced, and oral glucose tolerance showed that the glucose degradation rates of composite resistant starch were significantly improved compared to model mice. Cholesterol, triglycerides, high-density lipoprotein and low-density lipoprotein were significantly lower than those in the diabetes group (P < 0.05). The diversity of the gut microbiota was also proven.
羧甲基壳聚糖和抗性淀粉在调节糖尿病方面表现出良好的性能。我们制备了羧甲基壳聚糖-抗性淀粉复合物。通过 X 射线衍射、水接触角、红外光谱和扫描电子显微镜测试了复合抗性淀粉的性质，并进行了与肠道微生物群的相互作用和小鼠实验。结果表明，复合抗性淀粉对促进双歧杆菌等益生菌的增殖有很好的效果，对大肠杆菌的抑制作用明显优于抗性淀粉（P<0.05）。给药后，糖尿病小鼠的饮水量和体重明显减轻。糖尿病小鼠的血糖也降低了，口服葡萄糖耐量试验表明，与模型组相比，复合抗性淀粉的葡萄糖降解率有明显提高。胆固醇、甘油三酯、高密度脂蛋白和低密度脂蛋白均显著低于糖尿病组（P<0.05）。还证明了肠道微生物群的多样性。
