Wang Jun, Qin Yixin, Jiang Jingjing, Shan Hongyan, Zhao Changyu, Li Songnan
School of Tourism and Cuisine, Yangzhou University, Yangzhou 225127, China.
Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education of China, Institutes of Agricultural Science and Technology Development, Yangzhou University, Yangzhou 225009, China.
Foods. 2023 Oct 22;12(20):3865. doi: 10.3390/foods12203865.
With the development of diabetes, the gut microbiome falls into a state of dysbiosis, further affecting its progression. Theaflavins (TFs), a type of tea polyphenol derivative, show anti-diabetic properties, but their effect on the gut microbiome in diabetic mice is unclear. It is unknown whether the improvement of TFs on hyperglycemia and hyperlipidemia in diabetic mice is related to gut microbiota. Therefore, in this study, different concentrations of TFs were intragastrically administered to mice with diabetes induced by a high-fat-diet to investigate their effects on blood glucose, blood lipid, and the gut microbiome in diabetic mice, and the plausible mechanism underlying improvement in diabetes was explored from the perspective of the gut microbiome. The results showed that the TFs intervention significantly improved the hyperglycemia and hyperlipidemia of diabetic mice and affected the structure of the gut microbiome by promoting the growth of bacteria positively related to diabetes and inhibiting those negatively related to diabetes. The changes in short-chain fatty acids in mice with diabetes and functional prediction analysis suggested that TFs may affect carbohydrate metabolism and lipid metabolism by regulating the gut microbiome. These findings emphasize the ability of TFs to shape the diversity and structure of the gut microbiome in mice with diabetes induced by a high-fat diet combined with streptozotocin and have practical implications for the development of functional foods with TFs.
随着糖尿病的发展，肠道微生物群会陷入失调状态，进而影响其病情进展。茶黄素（TFs）是一种茶多酚衍生物，具有抗糖尿病特性，但其对糖尿病小鼠肠道微生物群的影响尚不清楚。目前尚不清楚TFs对糖尿病小鼠高血糖和高血脂的改善作用是否与肠道微生物群有关。因此，在本研究中，将不同浓度的TFs经胃内给予高脂饮食诱导的糖尿病小鼠，以研究其对糖尿病小鼠血糖、血脂及肠道微生物群的影响，并从肠道微生物群的角度探讨TFs改善糖尿病的可能机制。结果表明，TFs干预显著改善了糖尿病小鼠的高血糖和高血脂，并通过促进与糖尿病正相关细菌的生长和抑制与糖尿病负相关细菌的生长来影响肠道微生物群的结构。糖尿病小鼠短链脂肪酸的变化及功能预测分析表明，TFs可能通过调节肠道微生物群来影响碳水化合物代谢和脂质代谢。这些发现强调了TFs在塑造高脂饮食联合链脲佐菌素诱导的糖尿病小鼠肠道微生物群多样性和结构方面的能力，对开发含TFs的功能性食品具有实际意义。
