Institute of Nutrition and Health, Qingdao University, Qingdao 266021, China; School of Public Health, Qingdao University, Qingdao 266021, China; National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, China.
Institute of Nutrition and Health, Qingdao University, Qingdao 266021, China; School of Public Health, Qingdao University, Qingdao 266021, China.
Int J Biol Macromol. 2024 Mar;261(Pt 2):129812. doi: 10.1016/j.ijbiomac.2024.129812. Epub 2024 Feb 1.
The hypoglycemic effects of two recrystallized resistant starches, A-type (ARS) and B-type (BRS), were investigated in type 2 diabetic mice. Mice were treated with low-, medium-, or high-dose ARS, high-dose BRS, or high-dose ARS combined with BRS (ABRS). After 10 weeks of continuous intervention, the medium-dose ARS group showed a significant reduction in fasting blood glucose, area under the curve of glucose, triglyceride (P < 0.01), and low-density lipoprotein (P < 0.05) levels compared to the model group and an increase in high-density lipoprotein levels (P < 0.01). The peptide YY and glucagon-like peptide-1 levels in the high-dose ARS, BRS, and ABRS groups and the butyric acid yield in the medium-dose ARS and BRS groups were significantly increased (P < 0.01) compared to those in the model group. Medium- and high-dose ARS intervention efficiently increased the relative abundance of beneficial Bacteroidetes, Lactobacillus, Lachnospiraceae_NK4A136_group, and Faecalibaculum, and lowered the ratio of Firmicutes to Bacteroidetes. Overall, ARS exhibited greater advantages than BRS in lowering blood sugar levels.
研究了两种重结晶抗性淀粉（ARS），A型（ARS）和 B 型（BRS），对 2 型糖尿病小鼠的降血糖作用。用低、中、高剂量的 ARS、高剂量的 BRS 或高剂量的 ARS 与 BRS（ABRS）处理小鼠。经过 10 周的连续干预，与模型组相比，中剂量 ARS 组空腹血糖、血糖曲线下面积、甘油三酯（P < 0.01）和低密度脂蛋白（P < 0.05）水平显著降低，高密度脂蛋白水平升高（P < 0.01）。与模型组相比，高剂量 ARS、BRS 和 ABRS 组的肽 YY 和胰高血糖素样肽-1水平以及中剂量 ARS 和 BRS 组的丁酸产量均显著增加（P < 0.01）。中、高剂量 ARS 干预有效地增加了有益的拟杆菌、乳杆菌、Lachnospiraceae_NK4A136 组和粪杆菌的相对丰度，并降低了厚壁菌门与拟杆菌门的比例。总体而言，ARS 在降低血糖水平方面比 BRS 具有更大的优势。
