自体树突状细胞移植后儿童系统性红斑狼疮表现的显著改善：一例报告并文献复习

Putranto Terawan Agus, Purnama Yenny, Djatmiko Roedi, Yana Martina Lily, Sitepu Enda Cindylosa, Irfon Raoulian

Faculty of Medicine, Jakarta Veterans National Development University, Jakarta, Indonesia.

Cellcure Center, Gatot Soebroto Central Army Hospital, Jl. Abdul Rahman Saleh Raya No. 24 RT10/RW5, Jakarta 10410, Indonesia.

Ther Adv Vaccines Immunother. 2023 Sep 13;11:25151355231186005. doi: 10.1177/25151355231186005. eCollection 2023.

Dendritic cells (DC) are postulated to play a role in autoimmune diseases such as Systemic Lupus Erythematosus (SLE). We reported a 13-year-old female SLE patient who presents with chronic arthritis accompanied by persistent fever, dyspnea, sleep disturbance, headache, stomatitis, rash, and muscle weakness. The supporting examinations showed abnormal blood cell counts, positive antinuclear antibody profile, serositis, and neuropathy. Immunosuppressants failed to improve the condition. DC-based vaccine derived from autologous peripheral blood which was introduced with SARS-CoV-2 protein was given to this patient. There was a significant improvement in clinical and laboratory findings. Thus, DC immunotherapy appears to be a potential novel therapy for SLE that needs to be studied.

树突状细胞（DC）被认为在自身免疫性疾病如系统性红斑狼疮（SLE）中发挥作用。我们报告了一名13岁的女性SLE患者，她患有慢性关节炎，并伴有持续发热、呼吸困难、睡眠障碍、头痛、口腔炎、皮疹和肌肉无力。辅助检查显示血细胞计数异常、抗核抗体谱阳性、浆膜炎和神经病变。免疫抑制剂未能改善病情。给该患者接种了源自自体外周血并引入了SARS-CoV-2蛋白的基于DC的疫苗。临床和实验室检查结果有显著改善。因此，DC免疫疗法似乎是一种有待研究的潜在的SLE新型疗法。