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多曝光激光散斑对比分析系统的标定受到皮肤内灌注相关散射的限制。

Multiexposure laser speckle contrast analysis system calibration limited by perfusion-dependent scattering on the skin.

机构信息

University of Szeged, Department of Optics and Quantum Electronics, Szeged, Hungary.

出版信息

J Biomed Opt. 2023 Sep;28(9):096006. doi: 10.1117/1.JBO.28.9.096006. Epub 2023 Sep 15.

DOI:10.1117/1.JBO.28.9.096006
PMID:37720190
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10502513/
Abstract

SIGNIFICANCE

Application of multiexposure speckle contrast imaging (MESI) methods for perfusion measurements can correct for the contribution of static scattering of the skin, at the expense of reduced temporal resolution as compared to classical single-exposure methods. Persistence of tissue scattering properties during the measurements could allow for an initial calibration and enhancement of the temporal resolution of the measurements.

AIM

We aim to study the influence of the perfusion on the light scattering of the forearm skin and to use the obtained data for the enhancement of the temporal resolution.

APPROACH

A wide range of skin perfusion states was induced while monitoring the changes in the dynamic range of the exposure-dependent contrast. Different measurement and evaluation methods were tested based on an initial MESI calibration followed by image recording with reduced number of exposure time values.

RESULTS

The changes in the skin perfusion can alter not only the contribution of the static scattering to the speckle images but also the short-exposure time contrast limit.

CONCLUSIONS

The perfusion-dependent scattering of the skin can invalidate the precalibrations (e.g., calibration) characterizing the combination of the given tissue and the measurement system.

摘要

意义

应用多曝光散斑对比成像（MESI）方法进行灌注测量可以校正皮肤静态散射的影响，但与传统的单次曝光方法相比，其时间分辨率会降低。在测量过程中，组织散射特性的持续存在可以允许初始校准并提高测量的时间分辨率。

目的

我们旨在研究前臂皮肤的灌注对光散射的影响，并利用所获得的数据来提高时间分辨率。

方法

在监测曝光相关对比度的动态范围变化的同时，诱导广泛的皮肤灌注状态。基于初始 MESI 校准，测试了不同的测量和评估方法，然后记录曝光时间值减少的图像。

结果

皮肤灌注的变化不仅可以改变静态散射对散斑图像的贡献，还可以改变短曝光时间对比度的限制。

结论

皮肤的灌注相关散射会使表征特定组织和测量系统组合的预校准（例如，校准）失效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6af7/10502513/48556db54a63/JBO-028-096006-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6af7/10502513/381cea5a44c7/JBO-028-096006-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6af7/10502513/3c571ffb22fe/JBO-028-096006-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6af7/10502513/ec01d50d92f9/JBO-028-096006-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6af7/10502513/adcfe36d101d/JBO-028-096006-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6af7/10502513/25d875a91aa2/JBO-028-096006-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6af7/10502513/48556db54a63/JBO-028-096006-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6af7/10502513/381cea5a44c7/JBO-028-096006-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6af7/10502513/3c571ffb22fe/JBO-028-096006-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6af7/10502513/ec01d50d92f9/JBO-028-096006-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6af7/10502513/adcfe36d101d/JBO-028-096006-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6af7/10502513/25d875a91aa2/JBO-028-096006-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6af7/10502513/48556db54a63/JBO-028-096006-g006.jpg

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