Sabu Abraham, J Selvaraj, R Gayatridevi, E Dilipan
Department of Physiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 600077, Tamil Nadu, India.
Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 600077, Tamil Nadu, India.
Bioinformation. 2023 Jan 31;19(1):43-47. doi: 10.6026/97320630019043. eCollection 2023.
The medicinal herb is utilized by South Indian tribes to treat various medical ailments, although its cytotoxicity action has not been studied. As a result, the emphasis of the current investigation is on the anticancer activity of extracts on MCF-7 breast cancer cell lines, as well as their effects on the levels of gene expression for BCl2 and TGF. The study found that the anticancer activity of extract demonstrated significant cytotoxic activity against MCF-7 breast cancer cell lines. Because of this, its anticancer effect may be caused by apoptosis, which is caused by DNA breaking and is helped by active phytochemicals like alkaloids, phenols, and flavonoids in the extracts. It also promotes apoptosis by altering Bcl-2 and TGF expression levels. The present study suggests using extract as an anticancer agent in traditional medicine.
这种草药被南印度部落用于治疗各种疾病，尽管其细胞毒性作用尚未得到研究。因此，当前研究的重点是该提取物对MCF-7乳腺癌细胞系的抗癌活性，以及它们对BCl2和TGF基因表达水平的影响。研究发现，该提取物的抗癌活性对MCF-7乳腺癌细胞系表现出显著的细胞毒性活性。因此，其抗癌作用可能是由DNA断裂引起的细胞凋亡所致，提取物中的生物碱、酚类和黄酮类等活性植物化学物质有助于这种凋亡。它还通过改变Bcl-2和TGF表达水平来促进细胞凋亡。本研究建议在传统医学中使用该提取物作为抗癌剂。
