• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

从四叶萝芙木中作为人工产物获得的杂合单萜吲哚生物碱。

Hybrid Monoterpenoid Indole Alkaloids Obtained as Artifacts from Rauvolfia tetraphylla.

作者信息

Gao Yuan, Zhou Dong-Sheng, Hai Ping, Li Yan, Wang Fei

机构信息

BioBioPha Co., Ltd., Kunming, 650201, People's Republic of China.

Department of Chemical Engineering, Yibin University, Yibin, 644000, People's Republic of China.

出版信息

Nat Prod Bioprospect. 2015 Oct;5(5):247-53. doi: 10.1007/s13659-015-0074-2. Epub 2015 Sep 29.

DOI:10.1007/s13659-015-0074-2
PMID:26416155
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4607677/
Abstract

Five new hybrid monoterpenoid indole alkaloids bearing an unusual 2,2-dimethyl-4-oxopiperidin-6-yl moiety, namely rauvotetraphyllines F-H (1, 3, 4), 17-epi-rauvotetraphylline F (2) and 21-epi-rauvotetraphylline H (5), were isolated from the aerial parts of Rauvolfia tetraphylla. Their structures were established by extensive spectroscopic analysis. The new alkaloids were evaluated for their cytotoxicity in vitro against five human cancer cell lines.

摘要

从四叶萝芙木的地上部分分离出了五种带有不寻常的2,2-二甲基-4-氧代哌啶-6-基部分的新杂合单萜吲哚生物碱，即萝芙四叶林F-H（1、3、4）、17-表萝芙四叶林F（2）和21-表萝芙四叶林H（5）。通过广泛的光谱分析确定了它们的结构。对这些新生物碱进行了体外对五种人类癌细胞系的细胞毒性评估。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e9d/4607677/8ac60a0f97cc/13659_2015_74_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e9d/4607677/10525c834691/13659_2015_74_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e9d/4607677/ffdffc56b46f/13659_2015_74_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e9d/4607677/ee4684ea795a/13659_2015_74_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e9d/4607677/8ac60a0f97cc/13659_2015_74_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e9d/4607677/10525c834691/13659_2015_74_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e9d/4607677/ffdffc56b46f/13659_2015_74_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e9d/4607677/ee4684ea795a/13659_2015_74_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e9d/4607677/8ac60a0f97cc/13659_2015_74_Fig4_HTML.jpg

相似文献

1
Hybrid Monoterpenoid Indole Alkaloids Obtained as Artifacts from Rauvolfia tetraphylla.从四叶萝芙木中作为人工产物获得的杂合单萜吲哚生物碱。
Nat Prod Bioprospect. 2015 Oct;5(5):247-53. doi: 10.1007/s13659-015-0074-2. Epub 2015 Sep 29.
2
Hexacyclic monoterpenoid indole alkaloids from Rauvolfia verticillata.萝芙木中的六环单萜吲哚生物碱。
Fitoterapia. 2015 Dec;107:44-48. doi: 10.1016/j.fitote.2015.10.004. Epub 2015 Oct 22.
3
Spatial localization of monoterpenoid indole alkaloids in Rauvolfia tetraphylla by high resolution mass spectrometry imaging.利用高分辨率质谱成像技术对四叶萝芙木中吲哚类单萜生物碱进行空间定位
Phytochemistry. 2023 May;209:113620. doi: 10.1016/j.phytochem.2023.113620. Epub 2023 Mar 1.
4
UPLC and ESI-MS analysis of metabolites of Rauvolfia tetraphylla L. and their spatial localization using desorption electrospray ionization (DESI) mass spectrometric imaging.UPLC 和 ESI-MS 分析萝芙木化学成分及其利用解吸电喷雾电离质谱成像技术的空间定位
Phytochemistry. 2019 Mar;159:20-29. doi: 10.1016/j.phytochem.2018.11.009. Epub 2018 Dec 17.
5
Rauvomines A and B, Two Monoterpenoid Indole Alkaloids from Rauvolfia vomitoria.瑞香狼毒 A 和 B，瑞香狼毒中的两种单萜吲哚生物碱。
Org Lett. 2017 Aug 4;19(15):3998-4001. doi: 10.1021/acs.orglett.7b01723. Epub 2017 Jul 18.
6
Cytotoxic monoterpenoid indole alkaloids from the aerial parts of .来自……地上部分的细胞毒性单萜吲哚生物碱。 （你提供的原文不完整，这里只是按现有内容翻译）
J Asian Nat Prod Res. 2020 Aug;22(8):724-731. doi: 10.1080/10286020.2019.1621851. Epub 2019 Jun 1.
7
Alkaloids and Lignans from the Aerial Parts of Rauvolfia tetraphylla Inhibit NO Production in LPS-activated RAW 264.7 Cells.四叶萝芙木地上部分的生物碱和木脂素抑制脂多糖激活的RAW 264.7细胞中一氧化氮的产生。
Chem Biodivers. 2024 Mar;21(3):e202302123. doi: 10.1002/cbdv.202302123. Epub 2024 Feb 6.
8
Cytotoxic monoterpenoid indole alkaloids isolated from the barks of Voacanga africana Staph.从非洲沃坎加树（Voacanga africana Staph.）树皮中分离得到的细胞毒性单萜吲哚生物碱
Nat Prod Res. 2016;30(10):1144-9. doi: 10.1080/14786419.2015.1046132. Epub 2015 Jul 3.
9
3-oxo-rhazinilam: a new indole alkaloid from Rauvolfia serpentina x Rhazya stricta hybrid plant cell cultures.3-氧代-利血胺：一种从蛇根木×刺蕊草杂交植物细胞培养物中分离得到的新型吲哚生物碱。
J Nat Prod. 2001 Jan;64(1):114-6. doi: 10.1021/np000319x.
10
Cytotoxic monoterpenoid indole alkaloids from Alstonia yunnanensis Diels.云南鸡骨常山的细胞毒性单萜吲哚生物碱
Fitoterapia. 2017 Mar;117:79-83. doi: 10.1016/j.fitote.2016.12.011. Epub 2016 Dec 29.

引用本文的文献

1
A New Antimicrobial Phenylpropanol from the Leaves of Stapf. (Apocynaceae) Inhibits Pathogenic Gram-Negative Bacteria.一种从 Stapf.（夹竹桃科）叶子中提取的新型抗菌苯丙醇可抑制致病性革兰氏阴性菌。
Antibiotics (Basel). 2022 Jan 17;11(1):121. doi: 10.3390/antibiotics11010121.
2
Performances of Alkaloid Extract from Stapf toward Corrosion Inhibition of C38 Steel in Acidic Media.施塔夫生物碱提取物在酸性介质中对C38钢的缓蚀性能
ACS Omega. 2019 May 23;4(5):9081-9091. doi: 10.1021/acsomega.9b01076. eCollection 2019 May 31.
3
Clerodane Diterpenoids with Anti-hyperglycemic Activity from Tinospora crispa.

本文引用的文献

1
Indole alkaloids from the Marquesan plant Rauvolfia nukuhivensis and their effects on ion channels.来自马克萨斯群岛植物努库希瓦萝芙木的吲哚生物碱及其对离子通道的影响。
Phytochemistry. 2015 Jan;109:84-95. doi: 10.1016/j.phytochem.2014.10.026. Epub 2014 Nov 8.
2
Anti-prostate cancer activity of a beta-carboline alkaloid enriched extract from Rauwolfia vomitoria.一种从催吐萝芙木中提取的富含β-咔啉生物碱的提取物的抗前列腺癌活性
Int J Oncol. 2006 Nov;29(5):1065-73.
3
New alkaloids of the sarpagine group from Rauvolfia serpentina hairy root culture.
来自毛叶锡生藤的具有降血糖活性的克罗烷二萜类化合物。
Nat Prod Bioprospect. 2016 Oct;6(5):247-255. doi: 10.1007/s13659-016-0109-3. Epub 2016 Oct 17.
从蛇根木毛状根培养物中分离得到的萝芙木碱类新生物碱。
J Nat Prod. 2002 Jul;65(7):1006-10. doi: 10.1021/np0200919.
4
Indole alkaloids from Rauvolfia bahiensis A.DC. (Apocynaceae).来自巴伊亚萝芙木（夹竹桃科）的吲哚生物碱。
Phytochemistry. 2002 Jun;60(3):315-20. doi: 10.1016/s0031-9422(02)00122-x.
5
Interpretation of the formation of nine "artifact indole alkaloids" in the ajmaline/sarpagine series.阿吗灵/蛇根碱系列中九种“人工吲哚生物碱”形成的解读。
J Nat Prod. 2000 Oct;63(10):1456-60. doi: 10.1021/np000206d.
6
Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.用于细胞生长和存活的快速比色测定法：应用于增殖和细胞毒性测定。
J Immunol Methods. 1983 Dec 16;65(1-2):55-63. doi: 10.1016/0022-1759(83)90303-4.
7
Triacetonamine formation in fungal extracts.真菌提取物中三丙酮胺的形成。
J Agric Food Chem. 1975 Sep-Oct;23(5):1010-1. doi: 10.1021/jf60201a023.