Sah Monika, Saa Latheef, P Venkataramana
Discipline of Anthropology, School of Social Sciences, Indira Gandhi National Open University, Maidan Garhi, New Delhi-110068, India.
Department of Genetics, Osmania University, Hyderabad, India.
Bioinformation. 2023 Jan 31;19(1):19-23. doi: 10.6026/97320630019019. eCollection 2023.
In this study, an attempt was made to investigate the distribution of coronary risk factors in male patients with coronary artery disease (CAD)(n=50 each) belonging to Jaat and Vaishya castes. A Significantly higher average height, waist and hip circumferences, glucose, and waist-height ratio were observed in Jaats compared to the Vaishyas (p=0.000). Mean BMI, total cholesterol (total-C) and non-high density lipoprotein cholesterol (HDL-C), and lean body mass index (LBMI) were significantly higher in Vaishyas against Jaats (p=0.00). A significantly higher percentage of type 2 diabetes(T2DM) (p=0.03) and isolated hypertriglyceridemia(p=0.01) was observed in Jaats against Vaishya men. Percentage of general obesity(p=0.01), high total-C, high low density lipoprotein cholesterol (LDL-C) (p=0.00), high total-C/HDL-C(p=0.04), combined positive family history of hypertension and type 2 diabetes, and general obesity, was significantly higher in Vaishya when compared to Jaat men. In univariate logistic regression analyses, a significant association of T2DM (p=0.039) and isolated hypertriglyceridemia (p=0.020) with Jaat ethnic group and general obesity, high totalC, high LDL-C, and high total-C/HDL-C with Vaishya ethnic group was observed. Results of the present study suggest that a population-specific than a global approach should be used in identifying high-risk groups and designing of interventions to reduce the complications and management of CAD.
在本研究中，尝试调查属于贾特和吠舍种姓的男性冠心病（CAD）患者（各50例）中冠状动脉危险因素的分布情况。与吠舍相比，贾特人的平均身高、腰围和臀围、血糖及腰高比显著更高（p = 0.000）。吠舍人的平均体重指数、总胆固醇（总-C）和非高密度脂蛋白胆固醇（HDL-C）以及瘦体重指数（LBMI）显著高于贾特人（p = 0.00）。与吠舍男性相比，贾特人中2型糖尿病（T2DM）（p = 0.03）和单纯高甘油三酯血症（p = 0.01）的比例显著更高。与贾特男性相比，吠舍人中一般肥胖（p = 0.01）、高总-C、高低密度脂蛋白胆固醇（LDL-C）（p = 0.00）、高总-C/HDL-C（p = 0.04）、高血压和2型糖尿病合并阳性家族史以及一般肥胖的比例显著更高。在单因素逻辑回归分析中，观察到T2DM（p = 0.039）和单纯高甘油三酯血症（p = 0.020）与贾特族以及一般肥胖、高总C、高LDL-C和高总-C/HDL-C与吠舍族之间存在显著关联。本研究结果表明，在识别高危人群以及设计降低CAD并发症和管理CAD的干预措施时，应采用针对特定人群而非全球通用的方法。
