基于吲哚的二氮杂磺酰胺与JAK-3蛋白的分子对接分析
Molecular docking analysis of Indole based diaza-sulphonamides with JAK-3 protein.
作者信息
Nautiyal Manya, Sekaran Kavitha, Sekaran Surya, Rengasamy Gayathri, Veeraraghavan Vishnu Priya, Eswaramoorthy Rajalakshmanan
机构信息
Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai-600077.
Department of Biomaterials (Green lab), Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Science (SIMATS), Saveetha University, Chennai-600077.
出版信息
Bioinformation. 2023 Jan 31;19(1):74-78. doi: 10.6026/97320630019074. eCollection 2023.
JAK-3 gene is a part of an important signalling pathway in oral cancer. Therefore, it is of interest to evaluate the inhibitory properties of new indole based diaza-sulphonamides compounds against JAK3 gene. Molecular docking analysis showed that among the selected compounds (1-9), the compounds 1-4 turned out to be the most potentially capable ones to be used as ant-cancer drugs. Also, they are proved to be non-toxic.
JAK-3基因是口腔癌重要信号通路的一部分。因此，评估新型吲哚基二氮杂磺酰胺化合物对JAK3基因的抑制特性具有重要意义。分子对接分析表明，在所选择的化合物（1-9）中，化合物1-4被证明是最有潜力用作抗癌药物的。此外，它们被证明是无毒的。
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