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天然大黄素对宫颈癌的抗癌作用

Anticancer action of naturally occurring emodin for the controlling of cervical cancer.

作者信息

Lande Priyanka S, Adhao Vaibhav S, Ambhore Jaya P, Gaikwad Kiran P, Chandak Chanchal S, Joge Leena P

机构信息

Department of Quality Assurance, Dr. Rajendra Gode College of Pharmacy, Malkapur, Dist-Buldhana 443101, Maharashtra, India.

出版信息

Explor Target Antitumor Ther. 2023;4(4):690-698. doi: 10.37349/etat.2023.00161. Epub 2023 Aug 31.

Abstract

One of the major causes of death on the globe is cancer. The fourth most frequent malignancy in women worldwide is cervical cancer. Several cancer patients are remaining incurable due to the emergence of medication resistance, despite notable advances in cancer research over the previous few decades. The importance of natural sources as possible therapeutic candidates may be significant. Anthraquinones are one of the many chemical families of natural products, and they stand out for their wide range of structural variations, notable biological activity, and low toxicity. A natural substance called emodin, an anthraquinone derivative, is present in the roots and rhizomes of several plants. This substance has demonstrated antineoplastic, anti-inflammatory, antiangiogenic, and antiproliferative properties. It is also capable of preventing cancer spread and can reverse cancer cells' multidrug resistance. Emodin, a broad-spectrum inhibitor of cancer cells, have anticancer properties in many different types of biological pathways. These molecular mechanisms in cancer cells include the suppression of cell growth and proliferation, deterioration of the cell cycle arrest, the start of apoptosis, antimetastasis, and antiangiogenic impact. Therefore, the aim of the present review summarised the antiproliferative and anticarcinogenic qualities of cervical cancer of emodin.

摘要

全球主要死因之一是癌症。宫颈癌是全球女性中第四常见的恶性肿瘤。尽管在过去几十年癌症研究取得了显著进展,但由于耐药性的出现,仍有 several cancer patients 无法治愈。天然来源作为潜在治疗候选物的重要性可能很大。蒽醌是众多天然产物化学家族之一,因其结构变化广泛、显著的生物活性和低毒性而脱颖而出。一种名为大黄素的天然物质,是一种蒽醌衍生物,存在于几种植物的根和根茎中。这种物质已显示出抗肿瘤、抗炎、抗血管生成和抗增殖特性。它还能够防止癌症扩散,并可逆转癌细胞的多药耐药性。大黄素是一种广谱癌细胞抑制剂,在许多不同类型的生物途径中具有抗癌特性。癌细胞中的这些分子机制包括抑制细胞生长和增殖、细胞周期停滞的恶化、凋亡的启动、抗转移和抗血管生成作用。因此,本综述的目的总结了大黄素对宫颈癌的抗增殖和抗癌特性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4502/10501891/fbdfce6b001a/etat-04-1002161-g001.jpg

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