Lee Jinjoo, Jeong Myung In, Kim Hyo-Rim, Park Hyejin, Moon Won-Kyoung, Kim Bonglee
College of Korean Medicine, Kyung Hee University, Hoegi-dong Dongdaemun-gu, Seoul 05253, Korea.
Department of Pathology, College of Korean Medicine, Kyung Hee University, Hoegi-dong Dongdaemun-gu, Seoul 05253, Korea.
Antioxidants (Basel). 2020 Sep 7;9(9):836. doi: 10.3390/antiox9090836.
Cancer is a leading cause of the death worldwide. Since the National Cancer Act in 1971, various cancer treatments were developed including chemotherapy, surgery, radiation therapy and so forth. However, sequela of such cancer therapies and cachexia are problem to the patients. The primary mechanism of cancer sequela and cachexia is closely related to reactive oxygen species (ROS) and inflammation. As antioxidant properties of numerous plant extracts have been widely reported, plant-derived drugs may have efficacy on managing the sequela and cachexia. In this study, recent seventy-four studies regarding plant extracts showing ability to manage the sequela and cachexia were reviewed. Some plant-derived antioxidants inhibited cancer proliferation and inflammation after surgery and others prevented chemotherapy-induced normal cell apoptosis. Also, there are plant extracts that suppressed radiation-induced oxidative stress and cell damage by elevation of glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and regulation of B-cell lymphoma 2 (BcL-2) and Bcl-2-associated X protein (Bax). Cachexia was also alleviated by inhibition of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) by plant extracts. This review focuses on the potential of plant extracts as great therapeutic agents by controlling oxidative stress and inflammation.
癌症是全球主要的死亡原因之一。自1971年《国家癌症法案》颁布以来，人们开发了多种癌症治疗方法，包括化疗、手术、放射治疗等。然而，这些癌症治疗的后遗症和恶病质给患者带来了问题。癌症后遗症和恶病质的主要机制与活性氧（ROS）和炎症密切相关。由于众多植物提取物的抗氧化特性已被广泛报道，植物源药物可能对治疗后遗症和恶病质有效。在本研究中，我们回顾了最近74项关于植物提取物治疗后遗症和恶病质能力的研究。一些植物源抗氧化剂可抑制术后癌症增殖和炎症，另一些则可防止化疗诱导的正常细胞凋亡。此外，还有植物提取物通过提高谷胱甘肽（GSH）、超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GPx）以及调节B细胞淋巴瘤2（BcL-2）和Bcl-2相关X蛋白（Bax）来抑制辐射诱导的氧化应激和细胞损伤。植物提取物还可通过抑制肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）和单核细胞趋化蛋白-1（MCP-1）来缓解恶病质。本综述重点关注植物提取物通过控制氧化应激和炎症作为有效治疗药物的潜力。
