粘性可溶性膳食纤维对2型糖尿病患者糖脂代谢的影响：一项关于随机临床试验的系统评价和荟萃分析

Effect of viscous soluble dietary fiber on glucose and lipid metabolism in patients with type 2 diabetes mellitus: a systematic review and meta-analysis on randomized clinical trials.

作者信息

Lu Kun, Yu Tingqing, Cao Xinyi, Xia Hui, Wang Shaokang, Sun Guiju, Chen Liang, Liao Wang

机构信息

Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, China.

Public Service Platform of South China Sea for R&D Marine Biomedicine Resources, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, Guangdong, China.

出版信息

Front Nutr. 2023 Aug 31;10:1253312. doi: 10.3389/fnut.2023.1253312. eCollection 2023.

BACKGROUND

The effect of viscous soluble dietary fiber on glucose and lipid metabolism in type 2 diabetes mellitus (T2DM) remains controversial, and the dose-response relationship of its effect on blood glucose and blood lipid level is still unclear.

METHODS

We conducted comprehensive searches in several databases up to 17 January 2023. We conducted a dose-response analysis of randomized controlled trials (RCTs) to investigate the effect of viscous dietary fiber on glucose and lipid metabolism in patients with T2DM.

RESULTS

Statistical significance was observed in the decreases of glycosylated hemoglobin (HbA1c) (mean difference) [MD = -0.47; 95%CI: (-0.66, -0.27)], fasting blood glucose (FBG) [MD = -0.93; 95%CI: (-1.46, -0.41)], total cholesterol (TC) [MD = -0.33; 95%CI: (-0.46, -0.21)], and low-density lipoprotein and cholesterol (LDL-C) [MD = -0.24; 95%CI: (-0.35, -0.13)]. Contrarily, no difference was observed regarding the level of high-density lipoprotein cholesterol (HDL-C) or triglyceride (TG). In addition, the effect on fasting insulin remains unclear. Results from the subgroup analyses showed that an intervention duration longer than 6 weeks had a significant effect on the HbA1c level; a treatment dosage higher than 8.3 g/day had a significant effect on the FBG level.

CONCLUSIONS

Supplementation of viscous dietary fiber is beneficial to control blood glucose and blood lipid in T2DM.

背景

粘性可溶性膳食纤维对2型糖尿病（T2DM）患者糖脂代谢的影响仍存在争议，其对血糖和血脂水平影响的剂量反应关系尚不清楚。

方法

截至2023年1月17日，我们在多个数据库中进行了全面检索。我们对随机对照试验（RCT）进行剂量反应分析，以研究粘性膳食纤维对T2DM患者糖脂代谢的影响。

结果

糖化血红蛋白（HbA1c）（平均差）[MD = -0.47；95%置信区间：（-0.66，-0.27）]、空腹血糖（FBG）[MD = -0.93；95%置信区间：（-1.46，-0.41）]、总胆固醇（TC）[MD = -0.33；95%置信区间：（-0.46，-0.21）]以及低密度脂蛋白胆固醇（LDL-C）[MD = -0.24；95%置信区间：（-0.35，-0.13）]均出现显著下降。相反，高密度脂蛋白胆固醇（HDL-C）或甘油三酯（TG）水平未观察到差异。此外，对空腹胰岛素的影响尚不清楚。亚组分析结果显示，干预持续时间超过6周对HbA1c水平有显著影响；治疗剂量高于8.3 g/天对FBG水平有显著影响。